Psychometric liability to psychosis and childhood adversities are associated with shorter telomere length

Autor: Alp Üçok, Burcu Sırmatel, Sinan Guloksuz, Burcu Çevik, Güvem Gümüş-Akay, Eşref Cem Atbaşoğlu, Öykü Mançe-Çalışır, Jim van Os, Ajlan Tükün, Meram Can Saka, Köksal Alptekin
Přispěvatelé: Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: Hersen en Zenuw Centrum (3)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Psychometric liability to psychosis
STRESS
EROSION
Global Assessment of Functioning
Childhood trauma
0302 clinical medicine
EMOTIONAL INTELLIGENCE
STRUCTURED INTERVIEW
Adverse Childhood Experiences
Telomere Shortening
TRAUMA
Healthy siblings
education.field_of_study
Loneliness
Middle Aged
Resilience
Psychological
SIS
Psychiatry and Mental health
Schizophrenia
RELIABILITY
Female
Disease Susceptibility
medicine.symptom
Clinical psychology
Adult
Psychosis
Adolescent
Psychometrics
DISORDERS
Population
Psychological Trauma
MECHANISMS
Young Adult
03 medical and health sciences
Journal Article
medicine
Humans
Effects of sleep deprivation on cognitive performance
education
Biological Psychiatry
ENVIRONMENT
Telomere length
Resilience
business.industry
Siblings
medicine.disease
030227 psychiatry
Telomere
Psychotic Disorders
Non clinical
Gene-Environment Interaction
business
030217 neurology & neurosurgery
Zdroj: Journal of Psychiatric Research, 111, 169. Elsevier Limited
Journal of Psychiatric Research, 111, 169-185. Elsevier Science
ISSN: 1879-1379
0022-3956
Popis: Compared to the general population, individuals diagnosed with Schizophrenia (SCZ) experience a higher frequency and an earlier onset of chronic medical disorders, resulting in a reduction in life expectancy by an average of 15-25 years. Recently, it has been hypothesized that SCZ is a syndrome of accelerated aging. Childhood adversity was also associated with the pathogenesis and course of SCZ. Our hypothesis was that both SCZ patients and their unaffected siblings would have shorter telomere length (TL) compared to of non-clinical controls. Our additional goals were to determine (1) whether shorter TL correlates with intermediate phenotypes of SCZ (i.e. Psychosis-like symptoms and schizotypal traits); and (2) whether childhood adversities have a moderating role in TL shortening among SCZ and their unaffected siblings. To this end, SCZ patients (n = 100), their unaffected siblings (n = 100) and non-clinical controls (n = 100) were enrolled. The main variables were TL, measured by aTL-qPCR; psychotic-like and schizotypal symptoms, assessed by The Community Assessment of Psychic Experience (CAPE) and the Structured Interview for Schizotypy-Revised (SIS-R), respectively; and childhood adversities evaluated by the Childhood Experience of Care and Abuse (CECA)-Interview. Potentially relevant variables also included in the analyses were: Global Assessment of Functioning (GAF) scores, cognitive performance, and socio-demographic features. In contrast to our hypothesis patients had similar TL when compared to the non-clinical controls. Interestingly, unaffected siblings had longer TL compared to both patients and controls (p
Databáze: OpenAIRE
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