Bovine spinal muscular atrophy: AFG3L2 is not a positional candidate gene
| Autor: | J. Muntwyler, E. Ahrens, Gerald Stranzinger, M. L. Glowatzki-Mullis, H. Joerg, M. Asai-Coakwell |
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| Rok vydání: | 2005 |
| Předmět: |
Candidate gene
Cattle Diseases Locus (genetics) Biology Muscular Atrophy Spinal Atrophy Food Animals Genetic linkage medicine Animals Genetic Testing Allele In Situ Hybridization Fluorescence DNA Primers Adenosine Triphosphatases Genetics medicine.diagnostic_test Chromosome Mapping Chromosome Sequence Analysis DNA General Medicine Spinal muscular atrophy medicine.disease Molecular biology Pedigree Cattle Animal Science and Zoology Switzerland Microsatellite Repeats Fluorescence in situ hybridization |
| Zdroj: | Journal of Animal Breeding and Genetics. 122:103-107 |
| ISSN: | 1439-0388 0931-2668 |
| DOI: | 10.1111/j.1439-0388.2005.00489.x |
| Popis: | Bovine spinal muscular atrophy (BSMA) is a neurodegenerative disorder, which is widespread in Brown Swiss cattle. Main symptoms of the disease are muscular atrophy and recumbency. Affected calves die within few days or weeks. BSMA seems to be inherited as a recessive trait and the disease allele appears to have a common origin. In this study, a pedigree with 30 affected BSMA calves was used to genetically localize the BSMA locus. Linkage analysis was performed between microsatellite markers of seven chromosomes, where the homologous genes of human neurodegenerative disorders are located according to comparative mapping data, and the disease genotype. BSMA was mapped to chromosome 24 confirming the recently published localization (Medugorac et al. 2003). The candidate gene AFG3L2 was physically mapped to chromosome 24q24 using fluorescence in situ hybridization. Due to their different localizations AFG3L2 is not a positional candidate for BSMA. An informative marker localized on the telomeric side of the BSMA locus would be beneficial for marker-assisted selection as well as searching for the causative gene. However, finding a marker distal to BSMA locus is difficult because of its position at the end of the chromosome. |
| Databáze: | OpenAIRE |
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