Preventive effect of ultraviolet radiation on murine chronic sclerodermatous graft-versus-host disease

Autor: Pierre Tiberghien, Jean Sébastien Guerrini, Régis Angonin, Isabelle Mermet, François Kleinclauss, Aliette Marandin, Philippe Saas, François Aubin
Přispěvatelé: Département de dermatologie, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Hôpital Saint-Jacques-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté]), Service d'Anatomie pathologique [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Saas, Philippe, Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC)
Jazyk: angličtina
Rok vydání: 2007
Předmět:
MESH: Spleen
Graft vs Host Disease
Mice
0302 clinical medicine
immune system diseases
MESH: Animals
MESH: Bone Marrow Transplantation
Ultraviolet radiation
Bone Marrow Transplantation
MESH: Langerhans Cells
0303 health sciences
Mice
Inbred BALB C
integumentary system
Immunohistochemistry
3. Good health
medicine.anatomical_structure
surgical procedures
operative
Lymphocyte Transfusion
MESH: Lymphocyte Transfusion
[SDV.IMM]Life Sciences [q-bio]/Immunology
Clinical evaluation
[SDV.IMM] Life Sciences [q-bio]/Immunology
Ultraviolet Rays
MESH: Mice
Inbred BALB C
MESH: Graft vs Host Disease
Spleen
Mice
Inbred Strains
chemical and pharmacologic phenomena
MESH: Mice
Inbred Strains
MESH: Scleroderma
Limited
03 medical and health sciences
Scleroderma
Limited
medicine
MESH: Transplantation
Homologous
Animals
Transplantation
Homologous
Uvb irradiation
MESH: Mice
030304 developmental biology
Transplantation
business.industry
MESH: Immunohistochemistry
medicine.disease
Disease Models
Animal
Graft-versus-host disease
Murine model
Langerhans Cells
Immunology
MESH: Ultraviolet Rays
Bone marrow
MESH: Disease Models
Animal
business
030215 immunology
Zdroj: Transplantation
Transplantation, Lippincott, Williams & Wilkins, 2007, 84 (12), pp.1696-700. ⟨10.1097/01.tp.0000295934.34080.cc⟩
ISSN: 0041-1337
1534-6080
Popis: International audience; Although previous studies have demonstrated the efficient modulatory effects of ultraviolet radiation B (UVB) on cutaneous graft-versus-host disease (GVHD), most animal research on GVHD has been performed in murine models of acute GVHD. Here, we studied the preventive effect of UVB radiation on the occurrence of chronic sclerodermatous (Scl) GVHD in a murine model. Scl GVHD was induced by transplanting lethally irradiated BALB/c mice with B10.D2 bone marrow and spleen cells. Recipient mice were exposed to UVB before or after bone marrow and spleen cell infusion. Histological and clinical evaluation of GVHD was performed, in association with the characterization of epidermal Langerhans cells. UVB irradiation of recipients after, and more remarkably before, transplantation induced a decrease of Scl GVHD severity associated with epidermal Langerhans cells depletion. We conclude that UVB irradiation of recipient before or after transplantation has a preventive effect on cutaneous Scl GVHD and may represent an effective strategy for prevention of Scl GVHD.
Databáze: OpenAIRE
Externí odkaz: