Preventive effect of ultraviolet radiation on murine chronic sclerodermatous graft-versus-host disease
Autor: | Pierre Tiberghien, Jean Sébastien Guerrini, Régis Angonin, Isabelle Mermet, François Kleinclauss, Aliette Marandin, Philippe Saas, François Aubin |
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Přispěvatelé: | Département de dermatologie, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Hôpital Saint-Jacques-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté]), Service d'Anatomie pathologique [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Saas, Philippe, Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC) |
Jazyk: | angličtina |
Rok vydání: | 2007 |
Předmět: |
MESH: Spleen
Graft vs Host Disease Mice 0302 clinical medicine immune system diseases MESH: Animals MESH: Bone Marrow Transplantation Ultraviolet radiation Bone Marrow Transplantation MESH: Langerhans Cells 0303 health sciences Mice Inbred BALB C integumentary system Immunohistochemistry 3. Good health medicine.anatomical_structure surgical procedures operative Lymphocyte Transfusion MESH: Lymphocyte Transfusion [SDV.IMM]Life Sciences [q-bio]/Immunology Clinical evaluation [SDV.IMM] Life Sciences [q-bio]/Immunology Ultraviolet Rays MESH: Mice Inbred BALB C MESH: Graft vs Host Disease Spleen Mice Inbred Strains chemical and pharmacologic phenomena MESH: Mice Inbred Strains MESH: Scleroderma Limited 03 medical and health sciences Scleroderma Limited medicine MESH: Transplantation Homologous Animals Transplantation Homologous Uvb irradiation MESH: Mice 030304 developmental biology Transplantation business.industry MESH: Immunohistochemistry medicine.disease Disease Models Animal Graft-versus-host disease Murine model Langerhans Cells Immunology MESH: Ultraviolet Rays Bone marrow MESH: Disease Models Animal business 030215 immunology |
Zdroj: | Transplantation Transplantation, Lippincott, Williams & Wilkins, 2007, 84 (12), pp.1696-700. ⟨10.1097/01.tp.0000295934.34080.cc⟩ |
ISSN: | 0041-1337 1534-6080 |
Popis: | International audience; Although previous studies have demonstrated the efficient modulatory effects of ultraviolet radiation B (UVB) on cutaneous graft-versus-host disease (GVHD), most animal research on GVHD has been performed in murine models of acute GVHD. Here, we studied the preventive effect of UVB radiation on the occurrence of chronic sclerodermatous (Scl) GVHD in a murine model. Scl GVHD was induced by transplanting lethally irradiated BALB/c mice with B10.D2 bone marrow and spleen cells. Recipient mice were exposed to UVB before or after bone marrow and spleen cell infusion. Histological and clinical evaluation of GVHD was performed, in association with the characterization of epidermal Langerhans cells. UVB irradiation of recipients after, and more remarkably before, transplantation induced a decrease of Scl GVHD severity associated with epidermal Langerhans cells depletion. We conclude that UVB irradiation of recipient before or after transplantation has a preventive effect on cutaneous Scl GVHD and may represent an effective strategy for prevention of Scl GVHD. |
Databáze: | OpenAIRE |
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