The Hemolytic Action of Gramicidin and Tyrocidin
| Autor: | Keene P. Dimick |
|---|---|
| Rok vydání: | 1951 |
| Předmět: |
medicine.drug_class
Antibiotics Gramicidin Lysin Phospholipid medicine.disease Haemolysis Hemolysis General Biochemistry Genetics and Molecular Biology Anti-Bacterial Agents Red blood cell chemistry.chemical_compound medicine.anatomical_structure Biochemistry chemistry polycyclic compounds medicine Humans lipids (amino acids peptides and proteins) Dermatologic Agents Antibiotics Antitubercular Initial rate |
| Zdroj: | Experimental Biology and Medicine. 78:782-784 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-78-19217 |
| Popis: | Summary(1) The courses of hemolysis for gramicidin, tyrocidin, and mixtures of the two have been determined. Tyrocidin causes a rapid hemolysis, the extent being proportional to the concentration of the lysin. Gramicidin causes a slower initial rate of hemolysis but this initial lag is followed by rapid destruction of red blood cells at a rate at least equal to the initial rate due to tyrocidin. Mixtures of the two components gave hemolysis patterns characteristic of the proportions of gramicidin and tyrocidin. (2) An alcohol-soluble substance or substances present in the wall of the red blood cell of the rat, possibly phospholipid in nature, combines with tyrocidin, and to a lesser extent with gramicidin, causing them to lose their hemolytic activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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