A new α-pyrone from Arthrinium pseudosinense culture medium and its estrogenic activity in MCF-7 cells
| Autor: | Dongho Lee, Ki Sung Kang, Jae Jin Kim, Yuanqiang Guo, Sang Hee Shim, Quynh Nhu Nguyen, Ki-Hyun Kim, Haeun Kwon, Myung Woo Na, Joung Han Yim |
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| Rok vydání: | 2021 |
| Předmět: |
Magnetic Resonance Spectroscopy
medicine.drug_class Stereochemistry Chemical structure Breast Neoplasms Mass Spectrometry chemistry.chemical_compound Ascomycota Drug Discovery medicine Humans Cell Proliferation Pharmacology Arthrinium Estrogen Receptor alpha Absolute configuration Estrogens Pyrone chemistry MCF-7 Pyrones Estrogen Cancer cell MCF-7 Cells Phosphorylation Female |
| Zdroj: | The Journal of Antibiotics. 74:893-897 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.1038/s41429-021-00473-8 |
| Popis: | A new α-pyrone analog, arthrifuranone A (1) was isolated from an EtOAc-extract of Arthrinium pseudosinense culture medium. The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The chemical structure of the new compound was elucidated using MS and NMR spectroscopic techniques, and the absolute configuration was established by the Mosher's method and gauge-including atomic orbital NMR chemical shift calculations, followed by DP4 + analysis. The isolated compound was evaluated for its estrogenic activity using the MCF-7 estrogen responsive human breast cancer cells. Compound 1 showed estrogenic activity by increasing the proliferation of MCF-7 cells at the concentration of 3.125 μM via phosphorylation of estrogen receptor-α. |
| Databáze: | OpenAIRE |
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