Investigation of the Mannich reaction for generating a β-aminoketone: further treatment of kinetic results
| Autor: | Elham Aghdaei, Bahareh Mostafa, Sayyed Mostafa Habibi-Khorassani, Mehdi Shahraki |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
010405 organic chemistry
medicine.drug_class benzaldehyde 010402 general chemistry Kinetic energy 01 natural sciences 0104 chemical sciences Aminoketone Benzaldehyde chemistry.chemical_compound Aniline kinetic study chemistry Computational chemistry acetophenone medicine β-Aminoketone aniline lcsh:Science (General) Mannich reaction lcsh:Q1-390 Acetophenone |
| Zdroj: | Journal of Taibah University for Science, Vol 12, Iss 1, Pp 46-55 (2018) |
| ISSN: | 1658-3655 |
| Popis: | The aim of this study is the derivation of the kinetic parameters for a special Mannich reaction, where the first step is rate-determining. The work involved studying the reactions among benzaldehyde, acetophenone and aniline in the presence of sodium acetate as a catalyst for the generation a β-aminoketone. The novelty of this work lies in its investigation of the effect of the catalyst on kinetic behaviour that allows for estimations of the rate constant and activation parameters such as energy of activation, enthalpy, entropy and activation Gibbs free energy, relative to the formation of β-aminoketone. Experimentally, the reactions were found to be of second-order and the observed rate constants were determined using UV-vis spectrophotometry. The satisfactory agreement between the sets of experimental data obtained under different reaction conditions and the steady state assumption indicates that the assumptions made are correct and the whole treatment applied to the kinetic data is justified. |
| Databáze: | OpenAIRE |
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