Is Diet Sufficient as Laryngopharyngeal Reflux Treatment? A Cross‐Over Observational Study
| Autor: | Lise Crevier-Buchman, Antonino Maniaci, Lisa G. De Marrez, Jerome R. Lechien, Stéphane Hans, Sven Saussez, Lea Distinguin, Giannicola Iannella |
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| Přispěvatelé: | LPP - Laboratoire de Phonétique et Phonologie - UMR 7018 (LPP), Université Sorbonne Nouvelle - Paris 3-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Esophageal pH Monitoring low-fat acid beverage diet food gastroesophageal laryngopharyngeal natural plant protein reflux treatment 03 medical and health sciences Laryngopharyngeal reflux 0302 clinical medicine Internal medicine Electric Impedance Laryngopharyngeal Reflux medicine Humans Reflux symptom [SHS.LANGUE]Humanities and Social Sciences/Linguistics 030223 otorhinolaryngology ComputingMilieux_MISCELLANEOUS Control period Cross over business.industry Reflux University hospital medicine.disease 3. Good health Otorhinolaryngology 030220 oncology & carcinogenesis Observational study Sugars business Symptom score |
| Zdroj: | Laryngoscope Laryngoscope, Wiley, 2021, ⟨10.1002/lary.29890⟩ |
| ISSN: | 0023-852X |
| Popis: | OBJECTIVES/HYPOTHESIS To investigate the efficacy of low-fat, low-quick-release sugar, high-protein, alkaline, and plant-based diet as single treatment for patients with laryngopharyngeal reflux (LPR). STUDY DESIGN Cross-over observational study. METHODS Patients with LPR diagnosis at the hypopharyngeal-esophageal multichannel intraluminal impedance-pH-monitoring were prospectively recruited from the reflux clinic of three University Hospitals. Patients were instructed to follow low-fat, low-quick-release sugar, high-protein, alkaline, and plant-based diet for 6 to 12 weeks. Pre- to post-treatment symptom and finding changes were evaluated with reflux symptom score (RSS) and reflux sign assessment. Findings were compared to those of a control period where patients did not receive any treatment or diet. Diet was evaluated with refluxogenic diet score (REDS). RESULTS Fifty patients completed the study (19 males). Otolaryngological, digestive, and total RSS scores significantly improved from baseline to 6-week post-diet, while there were no significant changes during the control period. At 6-week post-diet, 37 (74%) patients reported significant symptom improvement or relief. Among them, symptoms continued to improve from 6 to 12 weeks in 27 cases, corresponding to a diet success rate of 54%. The REDS was predictive of the baseline RSS (P = .031). CONCLUSION Low-fat, low-quick-release sugar, high-protein, alkaline, and plant-based diet is an alternative cost-effective therapeutic approach for patients with LPR. Patients with higher REDS reported higher baseline symptom score. LEVEL OF EVIDENCE 3 Laryngoscope, 2021. |
| Databáze: | OpenAIRE |
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