Formulation and characterization of albumin microspheres containing norcantharidate for liver tumor targeting
| Autor: | Fang Yan, Bo Li, Fengping Shen, Qiang Fu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Biodistribution Materials science Metabolic Clearance Rate Surface Properties Chemistry Pharmaceutical Pharmaceutical Science Antineoplastic Agents Pharmacology Dialysis tubing Pharmacokinetics In vivo Albumins Animals Tissue Distribution Particle Size Drug Carriers Chromatography Liver Neoplasms Albumin General Medicine Bridged Bicyclo Compounds Heterocyclic Microspheres In vitro Rats Drug Liberation Liver Area Under Curve Emulsion Female Particle size Spleen Half-Life |
| Zdroj: | Drug Delivery. 22:862-868 |
| ISSN: | 1521-0464 1071-7544 |
| DOI: | 10.3109/10717544.2014.898715 |
| Popis: | The objectives of this study were first to encapsulate norcantharidate into albumin microspheres by the emulsion crosslinking method and second to characterize the microspheres in terms of the morphological examination, particle size, and encapsulation efficiency. The in vitro release of norcantharidate from the microspheres was studied by using the dialysis bag method. Pharmacokinetics and biodistribution studies were used to evaluate the advantages of microspheres than the conventional formulations. The microspheres prepared by crosslink emulsion were with uniform size, smooth surface, spherical shape, and disperse evenly. The particle size was uniform (13.3 ± 0.4 µm) and the encapsulation efficiency was 54.3 ± 4.18%. In vitro release indicated that the norcantharidate microspheres had a well-sustained release efficacy and fitted Korsmeyer's Peppas release model. In vivo studies showed that pharmacokinetics of norcantharidate microspheres could be described by the model of two-compartment after i.v. administration and had higher AUC inside liver and spleen than the injection group. No histological change occurred to the rat liver after the administration of norcantharidate microspheres. |
| Databáze: | OpenAIRE |
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