Prostate cancer survivors with symptoms of radiation cystitis have elevated fibrotic and vascular proteins in urine

Autor: Laura E. Lamb, Bernadette M.M. Zwaans, Michael B. Chancellor, Heinz E. Nicolai
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
medicine.medical_treatment
030232 urology & nephrology
Cancer Treatment
Urine
Gastroenterology
Prostate cancer
0302 clinical medicine
Cancer Survivors
Fibrosis
Cystitis
Medicine and Health Sciences
Medicine
Stage (cooking)
Immune Response
Multidisciplinary
Proteinuria
Prostate Cancer
Bladder and Ureteric Disorders
Prostate Diseases
Middle Aged
Oncology
030220 oncology & carcinogenesis
medicine.symptom
Anatomy
Research Article
Clinical Oncology
medicine.medical_specialty
Urology
Bladder
Science
Immunology
Radiation Therapy
Inflammation
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Internal medicine
Cancer Detection and Diagnosis
Humans
Radiation Injuries
business.industry
Cancer
Prostatic Neoplasms
Cancers and Neoplasms
Biology and Life Sciences
Renal System
medicine.disease
Radiation therapy
Genitourinary Tract Tumors
Blood Vessels
Clinical Medicine
business
Developmental Biology
Zdroj: PLoS ONE, Vol 15, Iss 10, p e0241388 (2020)
PLoS ONE
ISSN: 1932-6203
Popis: Radiation for pelvic cancers can result in severe bladder damage and radiation cystitis (RC), which is characterized by chronic inflammation, fibrosis, and vascular damage. RC development is poorly understood because bladder biopsies are difficult to obtain. The goal of this study is to gain understanding of molecular changes that drive radiation-induced cystitis in cancer survivors using urine samples from prostate cancer survivors with history of radiation therapy. 94 urine samples were collected from prostate cancer survivors with (n = 85) and without (n = 9) history of radiation therapy. 15 patients with radiation history were officially diagnosed with radiation cystitis. Levels of 47 different proteins were measured using Multiplex Luminex. Comparisons were made between non-irradiated and irradiated samples, and within irradiated samples based on radiation cystitis diagnosis, symptom scores or hematuria. Statistical analysis was performed using Welch's t-test. In prostate cancer survivors with history of radiation therapy, elevated levels of PAI 1, TIMP1, TIMP2, HGF and VEGF-A were detected in patients that received a radiation cystitis diagnosis. These proteins were also increased in patients suffering from hematuria or high symptom scores. No inflammatory proteins were detected in the urine, except in patients with gross hematuria and end stage radiation cystitis. Active fibrosis and vascular distress is detectable in the urine through elevated levels of associated proteins. Inflammation is only detected in urine of patients with end-stage radiation cystitis disease. These results suggest that fibrosis and vascular damage drive the development of radiation cystitis and could lead to the development of more targeted treatments.
Databáze: OpenAIRE
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