Nanofiber/hydrogel composite scaffold incorporated by silicon nanoparticles for sustained delivery of osteogenic factor: in vitro study

Autor:	Fereshteh Oustadi, Rana Imani, Masoumeh Haghbin Nazarpak, Ali Mohammad Sharifi, Steven J. P. McInnes
Přispěvatelé:	Oustadi, Fereshteh, Imani, Rana, Nazarpak, Masoumeh Haghbin, Sharifi, Ali Mohammad, McInnes, Steven JP
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	silicon nanoparticles Polymers and Plastics bone scaffold General Chemical Engineering drug delivery hydrogel nanofiber rosuvastatin Analytical Chemistry
Popis:	Utilizing bone scaffolds for osteogenic factors delivery has the vital advantage of faster and more efficient tissue regeneration. In this study, rosuvastatin calcium is loaded into the silicon nanoparticles and then incorporated into PLLA nanofibers followed by immersion into the gelatin hydrogel. The fabricated composites are characterized, and a drug release study shows that the nanofibers are the main barrier to drug release and provide sustained release for 21 days. Double encapsulation in the genipin-crosslinked gelatin hydrogel prolonged release to 32 days. The scaffold material shows great potential to provide a sustainable osteogenic factor delivery system. Refereed/Peer-reviewed
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae05f8d18ba7efec6df81033490c79bb https://hdl.handle.net/11541.2/32000 Zobrazit plný text záznamu