Secondary clonal hematologic neoplasia following successful therapy for acute promyelocytic leukemia (APL): A report of two cases and review of the literature
| Autor: | Daria Gaut, Gary J. Schiller, Joshua P. Sasine |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Acute promyelocytic leukemia
Monosomy medicine.medical_treatment FISH fluorescence in situ hybridization ATRA all-trans retinoic acid Acute myelocytic leukemia (AML) Bioinformatics lcsh:RC254-282 Therapy-related myelodysplastic syndrome (t-MDS) Article 03 medical and health sciences 0302 clinical medicine Myelodysplastic syndrome (MDS) Acute promyelocytic leukemia apl immune system diseases hemic and lymphatic diseases ATO arsenic trioxide medicine neoplasms Complete response Chromosome 7 (human) Chemotherapy PML-RARalpha promyelocytic leukemia/Retinoic acid receptor alpha business.industry Clonal hematopoiesis 6-MP 6-mercaptopurine Chromosome Hematology Secondary clone CR complete remission lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Oncology APL acute promyelocytic leukemia t-AML therapy-related acute myelocytic leukemia 030220 oncology & carcinogenesis t- MDS therapy-related myelodysplastic syndrome AML acute myelocytic leukemia ATG antithymyocyte globulin MDS myelodysplastic syndrome business 030215 immunology Therapy-related acute myelocytic leukemia (t-AML) |
| Zdroj: | Leukemia Research Reports Leukemia Research Reports, Vol 9, Iss, Pp 65-71 (2018) |
| ISSN: | 2213-0489 |
| Popis: | Although rare, secondary clonal hematologic neoplasia may occur after successful therapy for acute promyelocytic leukemia (APL). These secondary clonal events may be considered therapy-related, but may also be due to an underlying background of clonal hematopoiesis from which both malignancies may develop. In this manuscript, we describe two patients with secondary clones after APL therapy characterized in one patient by deletion of chromosome 11q23 and, in the other, by monosomy of chromosome 7, and also provide a review of all secondary clonal disorders described after APL therapy. We suggest that since most reports identify karyotypic abnormalities not typically associated with chemotherapy, there may be another mechanism underlying secondary clonal development after complete response to initial APL therapy. Keywords: Acute myelocytic leukemia (AML), Secondary clone, Myelodysplastic syndrome (MDS), Therapy-related acute myelocytic leukemia (t-AML), Therapy-related myelodysplastic syndrome (t-MDS) |
| Databáze: | OpenAIRE |
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