Corticotropin-releasing factor enhances inhibitory synaptic transmission to type III neurons in the bed nucleus of the stria terminalis
| Autor: | Soichiro Ide, Chikashi Maruyama, Yusuke Nagano, Fusao Kato, Katsuyuki Kaneda, Masabumi Minami |
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| Rok vydání: | 2015 |
| Předmět: |
endocrine system
medicine.medical_specialty Corticotropin-Releasing Hormone Neurotransmission Kynurenic Acid Inhibitory postsynaptic potential Synaptic Transmission Rats Sprague-Dawley chemistry.chemical_compound Kynurenic acid Extended amygdala Internal medicine medicine Animals Neurons General Neuroscience Miniature Postsynaptic Potentials Neural Inhibition Stria terminalis medicine.anatomical_structure Endocrinology Inhibitory Postsynaptic Potentials nervous system chemistry Tetrodotoxin Septal Nuclei Neuron Excitatory Amino Acid Antagonists Neuroscience Nucleus hormones hormone substitutes and hormone antagonists |
| Zdroj: | Neuroscience Letters. 600:56-61 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2015.05.059 |
| Popis: | We previously reported that corticotropin-releasing factor (CRF) increased neuronal excitability specifically in type II neurons of the dorsolateral part of the bed nucleus of the stria terminalis (dlBNST). Because the majority of type II dlBNST neurons are thought to be GABAergic interneurons, at least a portion of which are considered to regulate type III dlBNST neurons, it is possible that CRF increases inhibitory input to type III neurons through the activation of type II neurons in the dlBNST. To test this possibility, we examined the effect of CRF on type III dlBNST neurons using whole-cell voltage-clamp recordings of inhibitory postsynaptic currents (IPSCs) from rat BNST slices in the presence of kynurenic acid. Spontaneous IPSCs (sIPSCs) and miniature IPSCs (mIPSCs) were recorded in the absence and presence of tetrodotoxin, respectively. Bath application of CRF significantly increased the frequency of sIPSCs, indicating that CRF enhances the inhibitory input to type III neurons. CRF application failed to increase the frequency of mIPSCs, suggesting that CRF-induced increases in sIPSCs are dependent on action potentials. Combined with our previous finding that CRF specifically depolarizes type II dlBNST neurons, these results suggest that CRF may attenuate type III neuron excitation by augmenting the inhibitory influence of type II neurons in the dlBNST. |
| Databáze: | OpenAIRE |
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