Chrysin Induces Antidiabetic, Antidyslipidemic and Anti-Inflammatory Effects in Athymic Nude Diabetic Mice

Autor: Johann Saldaña-Ríos, Germán Bernal-Fernández, Angelica Nallelhy Rodriguez-Ocampo, Gabriela Ávila-Villarreal, Sara García-Jiménez, Rafael Villalobos-Molina, Samuel Estrada-Soto, Juan José Ramírez-Espinosa
Rok vydání: 2017
Předmět:
Blood Glucose
Male
0301 basic medicine
Interleukin-1beta
Anti-Inflammatory Agents
Pharmaceutical Science
Pharmacology
Analytical Chemistry
chrysin
chemistry.chemical_compound
0302 clinical medicine
Drug Discovery
Medicine
Chrysin
Hypolipidemic Agents
media_common
diabetes
Metformin
nude mice
Chemistry (miscellaneous)
030220 oncology & carcinogenesis
Cytokines
Molecular Medicine
medicine.symptom
medicine.drug
Drug
medicine.drug_class
media_common.quotation_subject
Mice
Nude
Context (language use)
Inflammation
Article
Anti-inflammatory
Diabetes Mellitus
Experimental
lcsh:QD241-441
03 medical and health sciences
lcsh:Organic chemistry
Diabetes mellitus
Animals
Hypoglycemic Agents
Physical and Theoretical Chemistry
Flavonoids
Triglyceride
Tumor Necrosis Factor-alpha
business.industry
Organic Chemistry
medicine.disease
antidyslipidemic
030104 developmental biology
chemistry
inflammation
business
Zdroj: Molecules; Volume 23; Issue 1; Pages: 67
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 23, Iss 1, p 67 (2017)
ISSN: 1420-3049
DOI: 10.3390/molecules23010067
Popis: Extensive knowledge of diabetes and its complications is helpful to find new drugs for proper treatment to stop degenerative changes derived from this disease. In this context, chrysin (5,7-dihydroxyflavone) is a natural product that occurs in a variety of flowers and fruits with anti-inflammatory and antidiabetic effects, among others. Thus, a diabetic model in athymic nude mice was developed and used to establish the ability of chrysin to decrease the secretion of pro-inflammatory cytokines. Also, it was determined the acute (50 mg/kg) and sub-acute (50 mg/kg/day/10 days) antidiabetic and antihyperlipidemic activities after the period of time treatment. Results indicate that chrysin has significant acute antihyperglycemic and antidiabetic effects in nude diabetic mice (p < 0.05). Moreover, triglyceride blood levels were reduced and IL-1β and TNF-α were diminished after 10 days’ treatment compared with control group (p < 0.05). In conclusion, it was found that chrysin could produce similar effects as metformin, a drug used for the treatment of diabetes, since both test samples decreased glucose and triglycerides levels, they impaired the generation of pro-inflammatory cytokines involved in the development of diabetes and its consequences, such as atherosclerosis and other cardiovascular diseases.
Databáze: OpenAIRE
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