Dual Antibacterial Effect of In Situ Electrospun Curcumin Composite Nanofibers to Sterilize Drug-Resistant Bacteria
| Autor: | Jun Zhang, Chun-Li Liu, Chen Yang, Zhi-Kai Cao, Seeram Ramakrishna, Jun Yang, Yun-Ze Long, Xiao-Han Bai, Da-Peng Yang |
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| Rok vydání: | 2021 |
| Předmět: |
Curcumin
Materials science medicine.medical_treatment Drug-resistant bacteria Photodynamic therapy 02 engineering and technology 010402 general chemistry 01 natural sciences chemistry.chemical_compound lcsh:TA401-492 medicine General Materials Science Nano Express Electrospinning biology Singlet oxygen Adhesion 021001 nanoscience & nanotechnology Condensed Matter Physics biology.organism_classification Naofibers 0104 chemical sciences Membrane Chemical engineering chemistry Nanofiber lcsh:Materials of engineering and construction. Mechanics of materials 0210 nano-technology Bacteria In situ deposition |
| Zdroj: | Nanoscale Research Letters, Vol 16, Iss 1, Pp 1-8 (2021) Nanoscale Research Letters |
| ISSN: | 1556-276X |
| Popis: | Bacterial infection especially caused by multidrug-resistant bacteria still endangers human life. Photodynamic therapy (PDT) can effectively kill bacteria, and nanofiber-based PDT can effectively reduce damage to normal tissues. However, current photosensitizers coated on the surfaces of fibers would release to the wound, causing some side effects. And nanofibers prepared by traditional method exhibit poor adhesion on the wound, which severely reduces the PDT effect due to its short-range effect. Herein, core–shell curcumin composite nanofibers are prepared by in situ electrospinning method via a self-made portable electrospinning device. The obtained composite nanofibers show superior adhesiveness on different biological surface than that of traditional preparation method. Upon 808-nm irradiation, these composite nanofibers effectively produced singlet oxygen (1O2) without curcumin falling off. After these composite nanofibers’ exposure to drug-resistant bacteria, they exhibit dual antibacterial behaviors and efficiently kill the drug-resistant bacteria. These dual antibacterial nanofiber membranes with excellent adhesiveness may benefit the application of wound infection as antibacterial dressing. Supplementary Information The online version contains supplementary material available at 10.1186/s11671-021-03513-2. |
| Databáze: | OpenAIRE |
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