Automated manipulation of zebrafish embryos using an electrothermal microgripper
| Autor: | Xuping Zhang, Huipeng Zhang, Yatao Zhang, Peng Song, Hongmiao Wei, Zhuo Zhang, Mingyu Cui, Dongming Tian, Guoning Si, Yueqing Yu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
010302 applied physics
animal structures Computer science 02 engineering and technology Limiting 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Electronic Optical and Magnetic Materials Hardware and Architecture embryonic structures 0103 physical sciences Zebrafish embryo Topological optimization Electrical and Electronic Engineering 0210 nano-technology Biomedical engineering |
| Zdroj: | Zhang, Z, Yu, Y, Song, P, Zhang, Y, Tian, D, Zhang, H, Wei, H, Cui, M, Si, G & Zhang, X 2020, ' Automated manipulation of zebrafish embryos using an electrothermal microgripper ', Microsystem Technologies, vol. 26, no. 6, pp. 1823-1834 . https://doi.org/10.1007/s00542-019-04728-1 |
| ISSN: | 1432-1858 0946-7076 |
| DOI: | 10.1007/s00542-019-04728-1 |
| Popis: | We present the first report on automated micro-manipulation of zebrafish embryos using an electrothermally-actuated microgripper. A five-bar linkage compliant microgripper, driven by a V-shaped electrothermal micro-actuator, is designed based on topological optimization. The electrothermally-actuated microgripper is fabricated, tested, and then integrated into a robotic micromanipulation system. The semi-automated manipulation of a single zebrafish embryo, as well as a series of comparison experiments, is carried out. Experimental results demonstrate that the microgripper has reliable capability of picking, moving, holding and releasing the zebrafish embryo. Specifically, it performs fairly well in immobilizing and limiting the excessive deformation of the embryo. Finally, based on teaching, the whole process of zebrafish embryo microinjection is programed and performed automatically, thus demonstrating great strengths and performance of the microgripper in zebrafish embryo micro-manipulation. |
| Databáze: | OpenAIRE |
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