Diagnostic significance of apparent diffusion coefficient values with diffusion weighted MRI in breast cancer: a meta- analysis
| Autor: | Li Jiang, Jiang-Hong Sun, Fei Guo, Xiu-Shi Zhang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
Epidemiology business.industry Public Health Environmental and Occupational Health Subgroup analysis Breast Neoplasms Odds ratio medicine.disease Sensitivity and Specificity Confidence interval Cohort Studies Breast cancer Diffusion Magnetic Resonance Imaging Oncology Meta-analysis Medicine Effective diffusion coefficient Humans Female business Nuclear medicine Cohort study Diffusion MRI |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 15(19) |
| ISSN: | 2476-762X |
| Popis: | Aims: Apparent diffusion coefficient (ADC) values of nodes in diffusion-weighted imaging (DWI) are widely used in differentiating metastatic from non-metastatic lymph nodes. The purpose of this meta-analysis was to demonstrate whether DWI could contribute to the precise diagnosis of breast cancer (BC) with and without lymph node metastasis (LNM). Materials and Methods: English and Chinese electronic databases were searched for relevant studies followed by a comprehensive literature search. Two reviewers independently assessed the methodological quality of the included trials based on the quality assessment of diagnostic accuracy studies (QUADAS). Summary odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were calculated. Results: Final analysis of 624 BC subjects (patients with LNM = 254, patients without LNM = 370) were incorporated into the current meta-analysis from 9 eligible cohort studies. Combined ORs of ADCs suggested that ADC values in BC patients without LNM were higher than in patients with LNM (OR=0.56, 95%CI: 0.11-1.01, p=0.015). Subgroup analysis stratified by country indicated a low ADC value in BC patients with LNM rather than those without LNM among Chinese (OR=1.27, 95%CI: 0.89-1.66, p |
| Databáze: | OpenAIRE |
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