Molecular architecture of the bacterial tripartite multidrug efflux pump focusing on the adaptor bridging model
| Autor: | Nam-Chul Ha, Saemee Song, Kangseok Lee, Jin-Sik Kim |
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| Rok vydání: | 2015 |
| Předmět: |
Models
Molecular Gram-negative bacteria biology Protein Conformation Biological Transport Active Membrane Transport Proteins Signal transducing adaptor protein General Medicine Periplasmic space biology.organism_classification Models Biological Applied Microbiology and Biotechnology Microbiology Cell biology Membrane Gram-Negative Bacteria Inner membrane Outer membrane efflux proteins Efflux Periplasmic Proteins Protein Multimerization Bacterial outer membrane Bacterial Outer Membrane Proteins |
| Zdroj: | Journal of Microbiology. 53:355-364 |
| ISSN: | 1976-3794 1225-8873 |
| Popis: | Gram-negative bacteria expel a wide range of toxic substances through tripartite drug efflux pumps consisting of an inner membrane transporter, an outer membrane channel protein, and a periplasmic adaptor protein. These pumps form tripartite assemblies which can span the entire cell envelope, including the inner and outer membranes. There have been controversial findings regarding the assembly of the individual components in tripartite drug efflux pumps. Recent structural and functional studies have advanced our understanding of the assembly and working mechanisms of the pumps. Here, we re-evaluate the assembly models based on recent structural and functional studies. In particular, this study focuses on the 'adaptor bridging model', highlighting the intermeshing cogwheel-like interactions between the tip regions of the outer membrane channel protein and the periplasmic adaptor protein in the hexameric assembly. |
| Databáze: | OpenAIRE |
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