Patterns of Bone Mineral Accretion and Sex Differences in Healthy Term Vitamin D Replete and Breastfed Infants From Montreal, Canada: Bone Mass Reference Data
| Autor: | Nathalie Gharibeh, Catherine A. Vanstone, Olusola F. Sotunde, Celia Rodd, Sina Gallo, Hope A. Weiler |
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| Rok vydání: | 2022 |
| Předmět: |
Male
musculoskeletal diseases Canada Endocrinology Diabetes and Metabolism Physiology 030209 endocrinology & metabolism law.invention 03 medical and health sciences Absorptiometry Photon 0302 clinical medicine Randomized controlled trial Bone Density Tandem Mass Spectrometry law 030225 pediatrics Vitamin D and neurology Humans Medicine Radiology Nuclear Medicine and imaging Orthopedics and Sports Medicine Vitamin D Bone growth Bone mineral Minerals Sex Characteristics business.industry Infant Newborn Infant Gestational age Repeated measures design musculoskeletal system 3. Good health Breast Feeding Bone mineral content Female business Chromatography Liquid Bone mass |
| Zdroj: | Journal of Clinical Densitometry. 25:43-53 |
| ISSN: | 1094-6950 |
| DOI: | 10.1016/j.jocd.2021.07.004 |
| Popis: | Infancy is a period of rapid bone growth and mineral accretion; nonetheless, reference data remain scarce for this age group. The purpose of this report is to generate reference data for bone mass in breastfed vitamin D replete infants and investigate patterns of bone mineral accretion and sex differences. This is a secondary analysis from a double-blinded randomized controlled trial (NCT00381914). Healthy term breastfed (exclusively or mixed) infants were randomized to different doses of oral vitamin D supplementation (400-1600 IU/d) and followed prospectively from 1 to 12 mo. Plasma 25-hydroxyvitamin D (LC-MS/MS), bone mineral content (BMC; whole body (WB) and lumbar spine (LS)) and bone mineral density (BMD; LS) were measured at 1, 3, 6, 9, and 12 mo by dual-energy x-ray absorptiometry (Hologic Discovery 4500A) with no effect of supplementation on bone outcomes. For the purpose of this analysis, 63 infants with adequate plasma 25-hydroxyvitamin D ≥ 50 nmol/L at baseline, were included. Differences over time and between sexes were tested using mixed model repeated measures ANOVA. Infants (31 males, 32 females) were 39.5 ± 1.1 wk gestational age at birth and appropriate for gestational age. WB BMC, LS BMC, and LS BMD increased by 143.2%, 116.8%, and 31.1% respectively across infancy. WB BMC was higher (4.2% - 9.4%; p = 0.03) in males than in females across the study. After adjusting WB BMC for weight, length or head BMC, sex differences were not evident. LS BMC and LS BMD did not vary by sex. LS BMD growth charts for both sexes combined, were generated using LMS chartmaker. WB BMC more than doubles during the first year of life confirming the importance of skeletal growth and the need for age-specific reference data in infancy. Sex differences in BMC, if any, are mostly driven by differences in body size. |
| Databáze: | OpenAIRE |
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