Polymorphism in AACT gene may lower age of onset of Alzheimerʼs disease
| Autor: | Christopher Talbot, Richard Crook, John Hardy, Mike Hutton, H. Houlden, Nicholas John Craddock, G. Prihar, Alison Goate, John C. Morris, C. Lendon |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Risk Apolipoprotein E Genotype alpha 1-Antichymotrypsin Population Late onset Alpha 1-antichymotrypsin Apolipoproteins E Alzheimer Disease Polymorphism (computer science) Humans Age of Onset Allele education Alleles Aged Genetics education.field_of_study Polymorphism Genetic biology General Neuroscience DNA Case-Control Studies Immunology biology.protein Female Age of onset |
| Zdroj: | Europe PubMed Central Scopus-Elsevier |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-199601310-00038 |
| Popis: | The ApoE-epsilon 4 allele is a predisposing factor for late onset Alzheimer's disease (AD), however it is neither necessary nor sufficient to cause the disease. A candidate for explaining part of the remaining genetic component is alpha 1-antichymotrypsin (AACT). In a case-control study we genotyped a polymorphism within the AACT gene to test for association with the disease. No allele of this gene showed an increased incidence among the population with AD compared with controls, even when taking ApoE genotype into account. This contrasts with the results of a recently published report. The mean age of onset was apparently lowered by the presence of the AACT AA genotype among ApoE-epsilon 4 bearers. If AACT genotype has an effect on risk for AD it may be predominantly amongst individuals with early onset AD. |
| Databáze: | OpenAIRE |
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