A double‐blind, placebo‐controlled, randomized study to evaluate the weight gain drug, mirtazapine transdermal ointment, in cats with unintended weight loss
| Autor: | Jessica M Quimby, Tianhua Hu, Daizie Labelle, Melinda Poole, William Buhles |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
040301 veterinary sciences Mirtazapine Population Appetite Stimulants Placebo Administration Cutaneous Cat Diseases 0403 veterinary science Ointments Random Allocation Double-Blind Method Weight loss Weight Loss medicine Scientific Papers Animals education Adverse effect Pharmacology education.field_of_study CATS General Veterinary medicine.diagnostic_test business.industry dysrexia 0402 animal and dairy science Complete blood count weight gain 04 agricultural and veterinary sciences 040201 dairy & animal science appetite Anesthesia transdermal Cats Original Article Female medicine.symptom business Weight gain medicine.drug |
| Zdroj: | Journal of Veterinary Pharmacology and Therapeutics |
| ISSN: | 1365-2885 0140-7783 |
| Popis: | Mirtazapine is classified as a weight gain drug in cats, and the purpose of this study was to evaluate its efficacy in cats experiencing unintended weight loss. This was a multi‐center, double‐blind, placebo‐controlled, randomized clinical study in client‐owned cats ≥1 year of age, weighing ≥2 kg, with a documented loss (≥5%) in body weight. Cats were treated once daily with either 2 mg/cat mirtazapine transdermal ointment (n = 83) or placebo (n = 94) (Per Protocol population) applied to the inner surface of the pinna for 14 ± 3 days. Physical examination, body weight, complete blood count, serum chemistry, and urinalysis were performed prior to treatment and on Day 14. Changes in body weight between the mirtazapine and placebo groups were evaluated from Day 1 to Day 14 and compared using a two‐sample t test. The mean percent change in body weight was +3.9% (standard deviation ±5.4%) in the mirtazapine group and +0.4% (±3.3%) in the placebo group (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text