Adrenergic Regulation of the Secretion of an Anticomplementary Factor in Mouse Saliva
| Autor: | Lane J. Wallace, D M Woodbury, M. E. Ellis, L.M. Partlow |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
Agonist Saliva Epinephrine medicine.drug_class medicine.medical_treatment Pharmacology General Biochemistry Genetics and Molecular Biology Mice Norepinephrine Thrombin medicine Animals Enzyme Inhibitors Receptor Complement Inactivator Proteins Chymotrypsin Protease biology Chemistry Isoproterenol Pilocarpine Kallikrein Trypsin Biochemistry biology.protein Salivation Trypsin Inhibitors Peptide Hydrolases medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 152:99-104 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-152-39337 |
| Popis: | Mouse saliva contains a potent inhibitor of complement activity. The secretion of this inhibitor appears to be regulated by action on alpha-adrenergic receptors for two reasons. First, an alpha-agonist (norepinephrine) elicited saliva with a 260-fold higher specific activity of the inhibitor than that obtained with a cholinergic agent (pilocarpine). Second, the alpha-agonist elicited saliva having 43-foldgreater specific activity than that obtained following administration of a beta-adrenergic agonist (isoproterenol). This anticomplementary factor probably proteolytically degrades one or more of the complement components since it is inhibited by several protease inhibitors. The salivary anticomplementary factor is more potent than trypsin, chymotrypsin, thrombin, or Kallikrein. The anticomplementary factor has a pattern of inhibition like that of Kallikrein but unlike those of trypsin or chymotrypsin. |
| Databáze: | OpenAIRE |
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