Evaluation of the CorInnova Heart Assist Device in an Acute Heart Failure Model
| Autor: | William E. Cohn, Christina M. Bolch, Boris Leschinsky, Egemen Tuzun, Erica C. Hord, John C. Criscione |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Acute failure medicine.medical_specialty Pharmaceutical Science Cardiac hemodynamics 030204 cardiovascular system & hematology Prosthesis Design Device implant Ventricular Function Left Prosthesis Implantation 03 medical and health sciences Temporary support Cardiac unloading 0302 clinical medicine Internal medicine Materials Testing Genetics medicine Animals Cardiac assist Heart assist Sheep Domestic Genetics (clinical) Heart Failure business.industry Hemodynamics Recovery of Function medicine.disease Esmolol Direct cardiac compression 3. Good health Disease Models Animal 030104 developmental biology Cardiac devices Heart failure CorInnova Cardiology Molecular Medicine Original Article Heart-Assist Devices Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Cardiovascular Translational Research |
| ISSN: | 1937-5395 1937-5387 |
| DOI: | 10.1007/s12265-018-9854-5 |
| Popis: | While the number of patients supported with temporary cardiac assist is growing, the existing devices are limited by a multitude of complications, mostly related to contact with the blood. The CorInnova epicardial compressive heart assist device was tested in six sheep using an acute heart failure model. High esmolol dose, targeting a 50% reduction in CO from healthy baseline, resulted in a failure state with mean CO 1.9 L/min. Heart assist with the device during failure state resulted in an average absolute increase in CO of 1.0 L/min, along with a decline in ventricular work to 67.5% of the total LV SW. Combined with repeated success of minimally invasive device implant, the resulting increases in cardiac hemodynamics achieved while still unloading the heart demonstrate the potential of the CorInnova device for temporary heart assist. Electronic supplementary material The online version of this article (10.1007/s12265-018-9854-5) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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