Expanding the family of tetrahalide iron complexes: synthesis, structure and biological applications
| Autor: | Abdullah Hamed A. Alshehri, Sheikh Alyza, Alan J. Hargreaves, Ali M.A. Almughrbi, Anthony J. Fitzpatrick, Nusrat Abedin, Felix Dafhnis-Calas, Olivia Moore, Elizabeth K. Rusbridge, Naqash Masood, Biola F. Egbowon |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Coordination sphere
010405 organic chemistry chemistry.chemical_element Protonation 010402 general chemistry 01 natural sciences Nitrogen Redox 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound Octahedron chemistry Oxidation state Bromide Biological property Polymer chemistry Materials Chemistry Physical and Theoretical Chemistry |
| ISSN: | 0277-5387 |
| Popis: | A neutral octahedral mononuclear iron(II) tetrabromide complex, [Fe(Hampy)2Br4], that consists of equatorial bromide and protonated aminopyrazinium axial ligands is successfully synthesised through redox chemistry and analysed using X-ray crystallography. The iron(II) oxidation state is balanced by the protonated pyrazinium nitrogen just outside the coordination sphere. The biological properties of this and two other related complexes are investigated using both Gram-negative and Gram-positive bacteria as well as methicillin resistant strains. They all exhibit some antimicrobial properties albeit at moderate to poor concentrations. However, the tetrahalide complexes analysed exhibit excellent anti biofilm properties well below cytotoxic levels. |
| Databáze: | OpenAIRE |
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