Formation and maintenance of blood–urine barrier in urothelium

Autor:	Kristijan Jezernik, Rok Romih, Samo Hudoklin, Mateja Erdani Kreft
Rok vydání:	2010
Předmět:	Cell Membrane Permeability Urinary bladder Tight junction Urinary Bladder Cell Biology Plant Science General Medicine Golgi apparatus Biology Endocytosis Cell biology symbols.namesake medicine.anatomical_structure symbols medicine Animals Humans Urothelium Barrier function BLOOD URINE Biogenesis
Zdroj:	Protoplasma. 246:3-14
ISSN:	1615-6102 0033-183X
DOI:	10.1007/s00709-010-0112-1
Popis:	Blood-urine barrier, which is formed during differentiation of superficial urothelial cells, is the tightest and most impermeable barrier in the body. In the urinary bladder, the barrier must accommodate large changes in the surface area during distensions and contractions of the organ. Tight junctions and unique apical plasma membrane of superficial urothelial cells play a critical role in the barrier maintenance. Alterations in the blood-urine barrier function accompany most of the urinary tract diseases. In this review, we discuss recent discoveries on the role of tight junctions, dynamics of Golgi apparatus and post-Golgi compartments, and intracellular membrane traffic during the biogenesis and maintenance of blood-urine barrier.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf24185716ecafd6307f227f080532c https://doi.org/10.1007/s00709-010-0112-1 Zobrazit plný text záznamu Full text from SpringerLink