Towards modeling anhedonia and its treatment in zebrafish
| Autor: | Murilo S de Abreu, Fabiano Costa, Ana C V V Giacomini, Konstantin A Demin, Konstantin N Zabegalov, Gleb O Maslov, Yuriy M Kositsyn, Elena V Petersen, Tatiana Strekalova, Denis B Rosemberg, Allan V Kalueff |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Pharmacology
MAJOR DEPRESSIVE DISORDER NUCLEUS-ACCUMBENS DOPAMINE antidepressant Behavior Animal Anhedonia DANIO-RERIO SOCIAL-INTERACTION behavior CONDITIONED PLACE PREFERENCE ADULT ZEBRAFISH zebrafish Antidepressive Agents animal models Psychiatry and Mental health Disease Models Animal STRESS-INDUCED ANHEDONIA BIOLOGICAL MECHANISMS ANIMAL-MODEL Animals Pharmacology (medical) RECOGNITION MEMORY |
| Zdroj: | International Journal of Neuropsychopharmacology. 25(4):293-306 |
| ISSN: | 1461-1457 |
| DOI: | 10.1093/ijnp/pyab092 |
| Popis: | Mood disorders, especially depression, are a major cause of human disability. The loss of pleasure (anhedonia) is a common, severely debilitating symptom of clinical depression. Experimental animal models are widely used to better understand depression pathogenesis and to develop novel antidepressant therapies. In rodents, various experimental models of anhedonia have already been developed and extensively validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of affective disorders, including depression. Here, we critically discuss the potential of zebrafish for modeling anhedonia and studying its molecular mechanisms and translational implications. |
| Databáze: | OpenAIRE |
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