Catheter-integrated soft multilayer electronic arrays for multiplexed sensing and actuation during cardiac surgery
| Autor: | Janice Mihyun Baek, Igor R. Efimov, Clifford Liu, Mengdi Han, Yonggang Huang, Kedar Aras, Roozbeh Ghaffari, Kan Li, Ndeye Rokhaya Faye, Guan-Jun Yang, Wubin Bai, Bohan Sun, Jae Hwan Kim, John A. Rogers, Xuexian Chen, Quansan Yang, Wei Lu, Cunman Liang, Hangbo Zhao, Jeffrey B. Model, Lin Chen, Yujin Lee, Enming Song, Yuhang Ma |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Computer science Radiofrequency ablation Heart Ventricles Multiphysics Finite Element Analysis Biomedical Engineering Medicine (miscellaneous) Bioengineering Multiplexing Cardiac Catheters law.invention 03 medical and health sciences 0302 clinical medicine law Monitoring Intraoperative Pressure Surgical skills Animals Humans Temperature Balloon catheter Equipment Design Irreversible electroporation Computer Science Applications Catheter Electroporation 030104 developmental biology Catheter Ablation Female Rabbits Electronics 030217 neurology & neurosurgery Biotechnology Biomedical engineering |
| Zdroj: | Nature Biomedical Engineering. 4:997-1009 |
| ISSN: | 2157-846X |
| DOI: | 10.1038/s41551-020-00604-w |
| Popis: | The rigidity and relatively primitive modes of operation of catheters equipped with sensing or actuation elements impede their conformal contact with soft-tissue surfaces, limit the scope of their uses, lengthen surgical times and increase the need for advanced surgical skills. Here, we report materials, device designs and fabrication approaches for integrating advanced electronic functionality with catheters for minimally invasive forms of cardiac surgery. By using multiphysics modelling, plastic heart models and Langendorff animal and human hearts, we show that soft electronic arrays in multilayer configurations on endocardial balloon catheters can establish conformal contact with curved tissue surfaces, support high-density spatiotemporal mapping of temperature, pressure and electrophysiological parameters and allow for programmable electrical stimulation, radiofrequency ablation and irreversible electroporation. Integrating multimodal and multiplexing capabilities into minimally invasive surgical instruments may improve surgical performance and patient outcomes. |
| Databáze: | OpenAIRE |
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