Modulatory effects of ayahuasca on personality structure in a traditional framework

Autor:	W. F. Tsang, Tom John Wolff, S. Linton, Simon Ruffell, Nige Netzband
Rok vydání:	2020
Předmět:	Adult Male Agreeableness Monoamine Oxidase Inhibitors Psychopharmacology media_common.quotation_subject Dimethyltryptamine 03 medical and health sciences 0302 clinical medicine Medical Tourism N N-Dimethyltryptamine Entheogen Surveys and Questionnaires Peru Openness to experience Humans Personality Mystical/peak experience media_common Original Investigation Neuroticism Pharmacology Plant Extracts Banisteriopsis Ayahuasca 030227 psychiatry Psilocybin Hallucinogens Female Psychedelic Personality Assessment Inventory Psychology 030217 neurology & neurosurgery Follow-Up Studies Mysticism Clinical psychology
Zdroj:	UnpayWall ORCID Microsoft Academic Graph PubMed Central Psychopharmacology
ISSN:	1432-2072 0033-3158
DOI:	10.1007/s00213-020-05601-0
Popis:	AbstractAyahuasca is a psychoactive plant brew containing dimethyltryptamine (DMT) and monoamine oxidase inhibitors (MAOIs). It originates from the Amazon basin, where it is used primarily for ceremonial purposes. Ayahuasca tourists are now entering certain communities seeking alternative physical or psychological healing, as well as spiritual growth.RationaleRecent evidence has shown that the similar acting psychedelic compound, psilocybin, facilitated long-term increases in trait openness following a single administration.ObjectivesThis paper assesses the impact of ayahuasca on personality in a traditional framework catering for ayahuasca tourists.MethodWithin a mixed design, we examined the effect of ayahuasca on participants’ personality (measured by the NEO Personality Inventory 3 questionnaire) across time (pre- to post-ayahuasca administration, and 6-month follow-up), relative to a comparison group (who did not ingest ayahuasca).ResultsThe results demonstrated significant increases in agreeableness pre- and post-ayahuasca administration and significant reductions in neuroticism in 24 participants, relative to the comparison group. Both of these changes were sustained at 6-month follow-up, and trait level increases were also observed in openness at this stage. Additionally, greater perceived mystical experience (measured using the Mystical Experience Questionnaire 30) was associated with increased reductions in neuroticism.ConclusionsThese findings, which indicate a positive mediating effect of ayahuasca on personality, support the growing literature suggesting potential therapeutic avenues for serotonergic psychedelics.
Databáze:	OpenAIRE
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