Overview of milling techniques for improving the solubility of poorly water-soluble drugs
| Autor: | Asim Kumar Samanta, Zhi Hui Loh, Paul Wan Sia Heng |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Drug
Cryomilling Materials science media_common.quotation_subject Pharmaceutical Science Nanotechnology law.invention Ball milling law Specific surface area Dissolution testing Crystallization Micronization Solubility Media milling media_common Pharmacology Drug solubility lcsh:RM1-950 technology industry and agriculture High pressure homogenization Bioavailability Crystallography Fluid energy milling Water soluble lcsh:Therapeutics. Pharmacology |
| Zdroj: | Asian Journal of Pharmaceutical Sciences, Vol 10, Iss 4, Pp 255-274 (2015) |
| ISSN: | 1818-0876 |
| DOI: | 10.1016/j.ajps.2014.12.006 |
| Popis: | Milling involves the application of mechanical energy to physically break down coarse particles to finer ones and is regarded as a “top–down” approach in the production of fine particles. Fine drug particulates are especially desired in formulations designed for parenteral, respiratory and transdermal use. Most drugs after crystallization may have to be comminuted and this physical transformation is required to various extents, often to enhance processability or solubility especially for drugs with limited aqueous solubility. The mechanisms by which milling enhances drug dissolution and solubility include alterations in the size, specific surface area and shape of the drug particles as well as milling-induced amorphization and/or structural disordering of the drug crystal (mechanochemical activation). Technology advancements in milling now enable the production of drug micro- and nano-particles on a commercial scale with relative ease. This review will provide a background on milling followed by the introduction of common milling techniques employed for the micronization and nanonization of drugs. Salient information contained in the cited examples are further extracted and summarized for ease of reference by researchers keen on employing these techniques for drug solubility and bioavailability enhancement. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|