Nuclear migration in mammalian brain development
| Autor: | Richard B. Vallee, Chiara Bertipaglia, João N.C. Gonçalves |
|---|---|
| Přispěvatelé: | Universidade do Minho |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Lissencephaly Biology Microtubules Nuclear envelope Nucleus 03 medical and health sciences 0302 clinical medicine Cell Movement medicine Molecular motor Animals Humans 10. No inequality Cytoskeleton Migration Progenitor Cell Nucleus Centrosome Science & Technology Brain Molecular motors Cell Biology Cell cycle medicine.disease Neural stem cell 030104 developmental biology nervous system Neuroscience 030217 neurology & neurosurgery Developmental Biology Adult stem cell |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| Popis: | During development of the mammalian brain, neural stem cells divide and give rise to adult stem cells, glia and neurons, which migrate to their final locations. Nuclear migration is an important feature of neural stem cell (radial glia progenitor) proliferation and subsequent postmitotic neuronal migration. Defects in nuclear migration contribute to severe neurodevelopmental disorders such as microcephaly and lissencephaly. In this review, we address the cellular and molecular mechanisms responsible for nuclear migration during the radial glia cell cycle and postmitotic neuronal migration, with a particular focus on the role of molecular motors and cytoskeleton dynamics in regulating nuclear behavior. The authors thank Dr. Tiago Dantas and Dr. Aditi Falnikar for critical reading of the manuscript. This work was supported by grants R01 HD40182 to R.V., and the FCT MDPhD Scholarship PD/BD/113766/2015 to J.C.G. |
| Databáze: | OpenAIRE |
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