Face-name associative memory performance is related to amyloid burden in normal elderly
| Autor: | Lauren E. Olson, Katherine Frishe, Jeremy Carmasin, Rebecca E. Amariglio, Reisa A. Sperling, Keith A. Johnson, J. Alex Becker, Meghan T. Frey, Dorene M. Rentz, Jacqueline E. Maye |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Clinical Dementia Rating Cognitive Neuroscience Precuneus Experimental and Cognitive Psychology Verbal learning Article Behavioral Neuroscience chemistry.chemical_compound Cognition Reference Values medicine Memory impairment Humans Cognitive reserve Aged Aged 80 and over Cerebral Cortex Memory Disorders Amyloid beta-Peptides Aniline Compounds Association Learning Retention Psychology Verbal Learning Thiazoles medicine.anatomical_structure chemistry Posterior cingulate Face Positron-Emission Tomography Female Pittsburgh compound B Psychology Neuroscience |
| Zdroj: | Neuropsychologia. 49(9) |
| ISSN: | 1873-3514 |
| Popis: | Cerebral amyloid beta (Aβ) deposition occurs in a substantial fraction of cognitively normal (CN) older individuals. However, it has been difficult to reliably detect evidence of amyloid-related cognitive alterations in CN using standard neuropsychological measures. We sought to determine whether a highly demanding face-name associative memory exam (FNAME) could detect evidence of Aβ-related memory impairment in CN. We studied 45 CN subjects (mean age = 71.7 ± 8.8) with Clinical Dementia Rating (CDR) scores = 0 and MMSE ≥ 28, using Positron Emission Tomography with Pittsburgh Compound B (PiB PET). Memory factor scores were derived from a principal components analysis for FNAME name retrieval (FN-N), FNAME occupation retrieval (FN-O) and the 6-Trial Selective Reminding Test (SRT). Using multiple linear and logistic regression analyses, we related the memory factor scores to PiB distribution volume ratios (DVR, cerebellar reference) as either a continuous or a dichotomous variable in frontal cortex and a posterior cortical region representing the precuneus, posterior cingulate and lateral parietal cortices (PPCLP), co-varying for age and AMNART IQ (a proxy of cognitive reserve (CR)). A significant inverse relationship for FN-N was found with Aβ deposition in frontal ( R 2 = 0.29, β = −2.2, p = 0.02) and PPCLP cortices ( R 2 = 0.26, β = −2.4, p = 0.05). In contrast, neither FN-O nor the SRT were significantly related to Aβ deposition. Performance on a demanding test of face-name associative memory was related to Aβ burden in brain regions associated with memory systems. Associative memory for faces and names, a common complaint among older adults, may be a sensitive marker of early Aβ-related impairment. |
| Databáze: | OpenAIRE |
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