Maternal protein restriction during lactation induces early and lasting plasma metabolomic and hepatic lipidomic signatures of the offspring in a rodent programming model

Autor: Patricia Parnet, Aurore Martin Agnoux, El Mostafa Qannari, Jean-Philippe Antignac, Marie-Cécile Alexandre-Gouabau, Anthony Pagniez, Angélina El Ghaziri, Gilles Simard, Thomas Moyon, Agnès David, Dominique Darmaun
Přispěvatelé: Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), Université de Nantes (UN), Stress Oxydant et Pathologies Métaboliques (SOPAM), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Centre hospitalier universitaire de Nantes (CHU Nantes), Laboratoire d'étude des Résidus et Contaminants dans les Aliments (LABERCA), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
medicine.medical_specialty
Metabolic imprinting
Offspring
Endocrinology
Diabetes and Metabolism

[SDV]Life Sciences [q-bio]
Clinical Biochemistry
Intrauterine growth restriction
Biology
Biochemistry
Antioxidants
Energy homeostasis
Rats
Sprague-Dawley

03 medical and health sciences
0302 clinical medicine
Pregnancy
Internal medicine
Lactation
metabolic programming
medicine
Metabolome
Animals
Metabolomics and lipidomics profiles
Molecular Biology
2. Zero hunger
Fetus
Fetal Growth Retardation
Nutrition and Dietetics
Perinatal maternal protein restriction
Fatty Acids
Maternal Nutritional Physiological Phenomena
Lipid Metabolism
medicine.disease
Animals
Suckling

Blood
030104 developmental biology
medicine.anatomical_structure
Endocrinology
Liver
Gestation
Female
Dietary Proteins
Transcriptome
030217 neurology & neurosurgery
Zdroj: The Journal of Nutritional Biochemistry
The Journal of Nutritional Biochemistry, 2018, 55, pp.124-141. ⟨10.1016/j.jnutbio.2017.11.009⟩
ISSN: 1873-4847
DOI: 10.1016/j.jnutbio.2017.11.009⟩
Popis: International audience; Perinatal undernutrition affects not only fetal and neonatal growth but also adult health outcome, as suggested by the metabolic imprinting concept. However, the exact mechanisms underlying offspring metabolic adaptations are not yet fully understood. Specifically, it remains unclear whether the gestation or the lactation is the more vulnerable period to modify offspring metabolic flexibility. We investigated in a rodent model of intrauterine growth restriction (IUGR) induced by maternal protein restriction (R) during gestation which time window of maternal undernutrition (gestation, lactation or gestation-lactation) has more impact on the male offspring metabolomics phenotype. Plasma metabolome and hepatic lipidome of offspring were characterized through suckling period and at adulthood using liquid chromatography-high-resolution mass spectrometry. Multivariate analysis of these fingerprints highlighted a persistent metabolomics signature in rats suckled by R dams, with a clear-cut discrimination from offspring fed by control (C) dams. Pups submitted to a nutritional switch at birth presented a metabolomics signature clearly distinct from that of pups nursed by dams maintained on a consistent perinatal diet. Control rats suckled by R dams presented transiently higher branched-chain amino acid (BCAA) oxidation during lactation besides increased fatty acid (FA) β-oxidation, associated with preserved insulin sensitivity and lesser fat accretion that persisted throughout their life. In contrast, IUGR rats displayed permanently impaired β-oxidation, associated to increased glucose or BCAA oxidation at adulthood, depending on the fact that pups experienced slow postnatal or catch-up growth, as suckled by R or C dams, respectively. Taken together, these findings provide evidence for a significant contribution of the lactation period in metabolic programming.
Databáze: OpenAIRE
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