Methadone vs morphine: Comparison of their effect on phagocytic functions
| Autor: | Claudio Santiangeli, Luisella Belogi, Ezio Tubaro, Giovanni Cavallo, Ustik Avico, Giorgio Borelli, Carlo M. Croce |
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| Předmět: |
Male
Neutrophils Ratón Phagocytosis Immunology Spleen Pharmacology Mice chemistry.chemical_compound Superoxides medicine Animals Propionibacterium acnes Mononuclear Phagocyte System Morphine business.industry Superoxide Macrophages Candidiasis Corpus albicans Pulmonary Alveoli medicine.anatomical_structure chemistry Toxicity business Methadone medicine.drug |
| Zdroj: | Scopus-Elsevier |
| Popis: | A comparison of the effects of methadone and morphine on phagocytic physiology was carried out in mice, using a number of tests, to estimate the risk of using methadone in maintenance protocols for opiates addicts. Results indicate that methadone, like morphine, reduces (a) R.E.S. activity and (b) PMN superoxide anion production, while unlike morphine it (a) does not produce haematologic changes, (b) does not exacerbate C. albicans infections, (c) does not inhibit phagocytosis and killing by murine polymorphonuclear leukocytes and macrophages, or by rabbit alveolar macrophages, and (d) does not reduce spleen and liver weight. These results are in strict agreement with those previously found in human subjects receiving controlled administration of morphine or methadone. Compared to morphine methadone therefore appears to have a lower toxic potentiality. |
| Databáze: | OpenAIRE |
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