Total cell-free DNA, carcinoembryonic antigen, and C-reactive protein for assessment of prognosis in patients with metastatic colorectal cancer
| Autor: | Christina Demuth, Estrid Hoegdall, Julia S. Johansen, Benny V. Jensen, Per Pfeiffer, Boe Sandahl Sorensen, K. L.G. Spindler, Dorte Nielsen, Niels Pallisgaard |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Male Colorectal cancer Denmark Cetuximab Cohort Studies 0302 clinical medicine Carcinoembryonic antigen Antineoplastic Combined Chemotherapy Protocols Medicine Everolimus/administration & dosage RC254-282 Aged 80 and over biology metastatic colorectal cancer Liver Neoplasms Neoplasms. Tumors. Oncology. Including cancer and carcinogens Colorectal Neoplasms/drug therapy General Medicine Middle Aged Prognosis Survival Rate C-Reactive Protein 030220 oncology & carcinogenesis Irinotecan/administration & dosage Female Colorectal Neoplasms Cell-Free Nucleic Acids Adult medicine.medical_specialty Adolescent Irinotecan Free dna Liver Neoplasms/drug therapy Biomarkers Tumor/analysis Cell-Free Nucleic Acids/analysis 03 medical and health sciences Young Adult Internal medicine Biomarkers Tumor Cell-free DNA plasma Humans Carcinoembryonic Antigen/metabolism In patient Everolimus Cetuximab/administration & dosage Aged business.industry C-Reactive Protein/metabolism C-reactive protein Total cell medicine.disease Carcinoembryonic Antigen 030104 developmental biology Case-Control Studies biology.protein Antineoplastic Combined Chemotherapy Protocols/therapeutic use Treatment decision making business Follow-Up Studies |
| Zdroj: | Tumor Biology, Vol 40 (2018) Spindler, K-L G, Demuth, C, Sorensen, B S, Johansen, J S, Nielsen, D, Pallisgaard, N, Hoegdall, E, Pfeiffer, P & Vittrup Jensen, B 2018, ' Total cell-free DNA, carcinoembryonic antigen, and C-reactive protein for assessment of prognosis in patients with metastatic colorectal cancer ', Tumor Biology, vol. 40, no. 11, pp. 1-8 . https://doi.org/10.1177/1010428318811207 Spindler, K-L G, Demuth, C, Sorensen, B S, Johansen, J S, Nielsen, D, Pallisgaard, N, Hoegdall, E, Pfeiffer, P & Vittrup Jensen, B 2018, ' Total cell-free DNA, carcinoembryonic antigen, and C-reactive protein for assessment of prognosis in patients with metastatic colorectal cancer ', Tumor Biology, vol. 40, no. 11, 1010428318811207 . https://doi.org/10.1177/1010428318811207 Spindler, K L G, Demuth, C, Sorensen, B S, Johansen, J S, Nielsen, D, Pallisgaard, N, Hoegdall, E, Pfeiffer, P & Vittrup Jensen, B 2018, ' Total cell-free DNA, carcinoembryonic antigen, and C-reactive protein for assessment of prognosis in patients with metastatic colorectal cancer ', Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, vol. 40, no. 11 . https://doi.org/10.1177/1010428318811207 |
| ISSN: | 1423-0380 |
| DOI: | 10.1177/1010428318811207 |
| Popis: | In late-stage metastatic colorectal cancer, difficult treatment decisions should incorporate a thorough evaluation of the patient’s general condition and subject for shared decision making. Assessment of the individual patients’ prognosis is valuable in this setting. The aim was to analyze the prognostic value of plasma levels of total cell-free DNA, carcinoembryonic antigen and C-reactive protein in 97 heavily pretreated patients with metastatic colorectal cancer. Patients received irinotecan, cetuximab, and everolimus in a phase-2 clinical trial ( clinicaltrials.gov NCT01387880). Plasma samples were used for DNA purification and quantification of total cell-free DNA by droplet digital polymerase chain reaction. Serum carcinoembryonic antigen and C-reactive protein were analyzed by routine methods. Clinical endpoints were overall survival and progression-free survival. A total of 82 patients had blood samples available for quantification of total cell-free DNA. Patients with pre-treatment cell-free DNA levels higher than the median total cell-free DNA (9800 alleles per milliliter plasma) had a significantly shorter overall survival of 4.3 months (95% confidence interval: 3.6–5.8) compared to patients with cell-free DNA levels below the median with an overall survival of 11.3 months (95% confidence interval: 8.0–14.8, p |
| Databáze: | OpenAIRE |
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