Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains

Autor:	Pei Shu, Chris Ebeling, George A. Carlson, John S. Smutko, Paul D. Markel, Karen J. Moore, Deborah L. Nagle
Rok vydání:	1997
Předmět:	Genetic Markers Male Mice Knockout Genetics Heterozygote Empirical data Models Genetic Strain (biology) Congenic Mice Inbred Strains Computational biology Breeding Congenic breeding Biology Mice Apolipoproteins E Trait Animals
Zdroj:	Nature Genetics. 17:280-284
ISSN:	1546-1718 1061-4036
Popis:	Congenic breeding strategies are becoming increasingly important as a greater number of complex trait linkages are identified. Traditionally, the development of a congenic strain has been a time-consuming endeavour, requiring ten generations of backcrosses. The recent advent of a dense molecular genetic map of the mouse permits methods that can reduce the time needed for congenic-strain production by 18-24 months. We present a theoretical evaluation of marker-assisted congenic production and provide the empirical data that support it. We present this 'speed congenic' method in a user-friendly manner to encourage other investigators to pursue this or similar methods of congenic production.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade62e08c9ddbff8ec0ab7b0464340c2 https://doi.org/10.1038/ng1197-280 Zobrazit plný text záznamu