Blood utilisation and transfusion reactions in adult patients transfused with conventional or pathogen‐reduced platelets
| Autor: | Bryan R. Spencer, Eric A. Gehrie, Edward L. Snyder, Wade L. Schulz, Amit Gokhale, Burak Bahar |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty efficacy Platelet Transfusion Gastroenterology 03 medical and health sciences 0302 clinical medicine Transfusion reaction Internal medicine Humans Medicine In patient Platelet Clinical efficacy Pathogen Adult patients business.industry Transfusion Transfusion Reaction Hematology Middle Aged Disinfection Red blood cell Increased risk medicine.anatomical_structure 030220 oncology & carcinogenesis platelets Female pathogen‐reduction business Research Paper 030215 immunology |
| Zdroj: | British Journal of Haematology |
| ISSN: | 1365-2141 0007-1048 |
| Popis: | Summary Pathogen‐reduced (PR) platelets are routinely used in many countries. Some studies reported changes in platelet and red blood cell (RBC) transfusion requirements in patients who received PR platelets when compared to conventional (CONV) platelets. Over a 28‐month period we retrospectively analysed platelet utilisation, RBC transfusion trends, and transfusion reaction rates data from all transfused adult patients transfused at the Yale‐New Haven Hospital, New Haven, CT, USA. We determined the number of RBC and platelet components administered between 2 and 24, 48, 72 or 96 h. A total of 3767 patients received 21 907 platelet components (CONV = 8912; PR = 12 995); 1,087 patients received only CONV platelets (1578 components) and 1,466 patients received only PR platelets (2604 components). The number of subsequently transfused platelet components was slightly higher following PR platelet components (P 0·05). Septic transfusion reactions (N = 5) were seen only after CONV platelet transfusions (P = 0·011). These results provide evidence for comparable clinical efficacy of PR and CONV platelets. PR platelets eliminated septic transfusion reactions without increased risk of other types of transfusions with only slight increase in platelet utilisation. |
| Databáze: | OpenAIRE |
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