Intravenous iron supplementation in distance runners with low or suboptimal ferritin
Autor: | Bev Anderson, Ruth Fazakerley, Philo U. Saunders, Laura A. Garvican, Christopher J. Gore, Iain C. Macdougall, Louisa Lobigs, Kieran Fallon, Kevin G. Thompson, Tanusha Cardoso, Judith Anson |
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Rok vydání: | 2013 |
Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent Anaerobic Threshold Administration Oral Physical Therapy Sports Therapy and Rehabilitation Ferric Compounds Running Hemoglobins Young Adult iron deficiency Oxygen Consumption Internal medicine medicine Humans Orthopedics and Sports Medicine Hematinic Maltose biology Transferrin saturation business.industry Lactate threshold Iron deficiency medicine.disease ferric carboxymaltose Surgery Ferritin Endocrinology hemoglobin mass Dietary Supplements Ferritins Running economy biology.protein Hematinics Physical Endurance Administration Intravenous Female Hemoglobin business VO2max Anaerobic exercise erythropoiesis |
Zdroj: | Medicine and science in sports and exercise. 46(2) |
ISSN: | 1530-0315 |
Popis: | Purpose: Iron deficiency is prevalent in distance runners and may impair endurance performance. The current practice of oral supplementation is slow and often not well tolerated. The aim of this study was to assess the efficacy of intravenous (IV) iron supplementation (ferric carboxymaltose) compared with oral supplementation (ferrous sulfate) on iron status, hemoglobin mass (Hbmass), and physiological indices of running performance in distance runners. Methods: Twenty-seven highly trained distance runners with low (LOW) (ferritin < 35 [mu]g[middle dot]L-1 and transferrin saturation < 20%, or ferritin < 15 [mu]g[middle dot]L-1) or suboptimal (SUB) iron status (ferritin < 65 [mu]g[middle dot]L-1) were supplemented with either IV iron (Ferinject(R)) or oral (ORAL) supplements (Ferrogradumet) for 6 wk. Iron status and Hbmass were assessed before supplementation and at 1, 2, 4, 6, and 8 wk in the four groups (IV LOW, IV SUB, ORAL LOW, and ORAL SUB). In addition, athletes completed a treadmill running test for running economy, lactate threshold, and V[spacing dot above]O2max before and after supplementation. Results: Both forms of supplementation substantially increased ferritin levels in all four groups. IV supplementation resulted in higher ferritin in both IV groups compared with both ORAL groups from week 1 onward. Hemoglobin concentration did not change substantially in any group. Hbmass increased in IV LOW (mean = +4.9%, 90% confidence interval [CI] = 1.1%-8.9%) and was accompanied by an increase in V[spacing dot above]O2max (mean = +3.3%, 90% CI = 0.4%-6.3%) and run time to exhaustion (mean = +9.3%, 90% CI = 0.9%-18.3%. Conclusions: IV supplementation can effectively increase iron stores in iron-deficient runners within 6 wk and, if Hbmass is compromised, may enhance endurance capacity by facilitating erythropoiesis. Hbmass appears a more sensitive tool for measuring changes in whole body hemoglobin than hemoglobin concentration and may be useful in the diagnosis and follow-up for iron deficiency. |
Databáze: | OpenAIRE |
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