An Internal Dose Model of Incapacitation and Lethality Risk from Inhalation of Fire Gases

Autor:	James H. Stuhmiller, Louise M. Stuhmiller, Diane W Long
Rok vydání:	2006
Předmět:	Health Toxicology and Mutagenesis Nitrogen Dioxide education Population Toxicology Models Biological Fires Mice Species Specificity Hydrogen Cyanide Smoke Statistics Animals Acrolein Carbon Monoxide Inhalation Exposure education.field_of_study Inhalation Chemistry Haplorhini Carbon Dioxide Toxic gas Rats Internal dose Breathing Probability distribution Lethality Gases Hydrochloric Acid Large animal
Zdroj:	Inhalation Toxicology. 18:347-364
ISSN:	1091-7691 0895-8378
DOI:	10.1080/08958370500516010
Popis:	A mathematical model for estimating the likelihood of incapacitation and lethality from the inhalation of toxic gases is presented. The model computes an internal dose, equal to retained toxic gas per body mass, which is used to extrapolate outcomes across species. Account is taken for ventilation changes due to species, activity, and chemical response. The internal dose is correlated with each outcome using a cumulative, log-normal, probability distribution, which allows the estimation of tolerances for any population incidence. No internal interactions of gases are modeled and probabilities are combined independently. The model compares favorably with combined gas and large animal data.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adde284d77ab82e8e2bdbd6588e2f573 https://doi.org/10.1080/08958370500516010 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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