The association of HLA class II DR B1 alleles with HCV infection in Egyptian children
Autor: | Rabab Fouad, Ahmed El-Hennawy, Ayman Yosry, Mona S. El-Raziky, Sherine Mahmoud, Mona A. Ghoneim |
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Rok vydání: | 2011 |
Předmět: |
Male
Adolescent Genotype Biopsy Human leukocyte antigen medicine.disease_cause Polymerase Chain Reaction Virus Gene Frequency Antigen medicine Humans Aspartate Aminotransferases Child HLA-DRB1 Serum Albumin Hepatitis B virus medicine.diagnostic_test Platelet Count business.industry Gastroenterology Case-control study HLA-DR Antigens Hepatitis C Chronic Liver Case-Control Studies Child Preschool Liver biopsy Immunology Egypt Female business HLA-DRB1 Chains |
Zdroj: | Arab Journal of Gastroenterology. 12:25-28 |
ISSN: | 1687-1979 |
DOI: | 10.1016/j.ajg.2011.01.007 |
Popis: | Background and study aims Human leucocyte antigens (HLA) class II appear to play an important role in the individual’s immune response to viral infection. The aim of this study is to assess the relationship between HLA class II antigens with the clinical, laboratory and histopathological state of the liver in Egyptian children and adolescents with chronic hepatitis C virus (HCV) infection. Patients and methods The study included 46 chronically infected HCV children and adolescents without – hepatitis B virus (HBV) nor human immunodeficiency virus – (HIV). Their mean age was 10.4 ± 4.23 years (3–17). HLA-DRB typing was done by polymerase chain reaction (PCR) for the patients and 20 control subjects. Biochemical and haematological parameters were assessed as well as a liver biopsy was taken from the included patients. Results The most frequent alleles demonstrated among patients were DRB1∗03, DRB1∗04 and DRB1∗13 (45.6%, 39.1% and 26.1%), respectively. Analysis of DRB1 frequencies between patients and control revealed that DRB1*15 is significantly reduced among patients when compared with the control group ( p p = 0.03), and this allele was presented to a greater extent in patients with minimal grade of inflammation. Patients with DRB1*04 had significantly low serum albumin ( p = 0.04) and patients with DRB1*13 had significantly high serum aspartate aminotransferase (AST) levels ( p = 0.05). Conclusion In Egyptian HCV-infected children, special HLA patterns were found; HLA DRB1*03 was present in nearly half of the patients, while the frequency of HLA DRB1*15 was significantly reduced among the cases in comparison to the control subjects. |
Databáze: | OpenAIRE |
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