Anti-inflammatory and nephroprotective activity of Juglans mollis against renal ischemia–reperfusion damage in a Wistar rat model
| Autor: | Gabriela Alarcón-Galván, Jonathan Pérez-Meseguer, Jorge Aurelio Gutiérrez-González, Linda E. Muñoz-Espinosa, Liliana Torres-González, Homero Zapata-Chavira, Diana Patricia Moreno-Peña, Paula Cordero-Pérez, Noemí Waksman de Torres |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant medicine.drug_class medicine.medical_treatment Anti-Inflammatory Agents Juglans Kidney medicine.disease_cause Anti-inflammatory Proinflammatory cytokine Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Malondialdehyde Internal medicine medicine Animals Humans Rats Wistar Blood urea nitrogen Creatinine Juglans mollis biology Plant Extracts Superoxide Dismutase Tumor Necrosis Factor-alpha Chemistry General Medicine lcsh:Other systems of medicine lcsh:RZ201-999 Ischemia–reperfusion Rats 030205 complementary & alternative medicine Endocrinology Complementary and alternative medicine Oxidative stress Reperfusion Injury 030220 oncology & carcinogenesis biology.protein Research Article |
| Zdroj: | BMC Complementary and Alternative Medicine, Vol 19, Iss 1, Pp 1-9 (2019) BMC Complementary and Alternative Medicine |
| ISSN: | 1472-6882 |
| DOI: | 10.1186/s12906-019-2604-7 |
| Popis: | Background Oxidative stress and the inflammatory process are involved in ischemia–reperfusion (I/R) injury. Juglans mollis has been reported as having antioxidant activity, which could attenuate the damage caused by I/R. We evaluated whether a methanolic extract of Juglans mollis (JM) exhibits nephroprotective activity in a Wistar rat model of I/R injury. Methods Four groups of six rats were used: Sham, I/R, JM, and JM + I/R. Two groups were dosed with JM (300 mg/kg) for 7 days before I/R. I/R injury was induced by clamping the renal hilums for 45 min and then reperfusing the kidneys for 15 h. Blood samples were taken to evaluate the levels of alanine aminotransferase (ALT), blood urea nitrogen, creatinine, superoxide dismutase (SOD), malondialdehyde (MDA), interleukin 1β (IL-1β), IL-6, and tumor necrosis factor α (TNF-α). Results The levels of creatinine, ALT, MDA, IL-1β, IL-6, and TNF-α were lower in JM + I/R than in I/R rats, whereas SOD level only was higher in JM + I/R than in Sham rats. No biochemical or histological damage was observed in JM rats compared with Sham rats; however, less histological damage was observed in JM + I/R rats compared with I/R rats. Conclusions To our knowledge, this is the first report of nephroprotective activity of J. mollis against damage induced by I/R. This activity may be related to decreased levels of proinflammatory cytokines (IL-1β, IL-6, and TNF-α) and modulation of oxidative stress markers (SOD and MDA) observed in the present study. |
| Databáze: | OpenAIRE |
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