Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC [Corrigendum]
| Autor: | Liang Kong, Shi-meng Zhang, Jia-hao Chu, Xin-ze Liu, Lu Zhang, Si-yu He, Si-min Yang, Rui-jun Ju, Xue-tao Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Epithelial-Mesenchymal Transition
Lung Neoplasms Biophysics Mice Nude Pharmaceutical Science Antineoplastic Agents Bioengineering Polyethylene Glycols Biomaterials Cell Movement International Journal of Nanomedicine Carcinoma Non-Small-Cell Lung Drug Discovery Tumor Microenvironment Animals Humans Neoplasm Invasiveness Mice Inbred BALB C Cell Death Neovascularization Pathologic Hydrolysis Phosphatidylethanolamines Organic Chemistry Vinorelbine General Medicine Endocytosis A549 Cells Liposomes Corrigendum Chickens |
| Zdroj: | International Journal of Nanomedicine |
| ISSN: | 1178-2013 |
| Popis: | Non-small cell lung cancer (NSCLC) is one of the most lethal types of cancer with highly infiltrating. Chemotherapy is far from satisfactory, vasculogenic mimicry (VM) and angiogenesis results in invasion, migration and relapse.The objective of this study was to construct a novel CPPThe targeting liposomes could be enriched in tumor sites through passive targeting, and the positively charged CPP was exposed and enhanced active targeting via electrostatic adsorption after being hydrolyzed by MMP2 enzymes overexpressed in the tumor microenvironment. We found that CPPCPP |
| Databáze: | OpenAIRE |
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