Vitamin D3, lactose, and xylitol stimulate chromaffin cell proliferation in the rat adrenal medulla
| Autor: | R. Michael McClain, Arthur S. Tischler, J C Downing, James F. Powers, Jeffrey Ziar, Jocelyn C. Riseberg, Mehzad Shahsavari |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Vitamin
Male endocrine system medicine.medical_specialty Calcitriol Chromaffin Cells Lactose Toxicology Xylitol Kidney chemistry.chemical_compound Internal medicine medicine Animals Cholecalciferol Pharmacology Cell growth Body Weight Organ Size Diet Rats medicine.anatomical_structure Endocrinology chemistry Adrenal Medulla Chromaffin cell Calcium Adrenal medulla Homeostasis Cell Division medicine.drug |
| Zdroj: | Toxicology and applied pharmacology. 140(1) |
| ISSN: | 0041-008X |
| Popis: | Chronic consumption by rats of diets rich in sugars or sugar alcohols leads to an increased incidence of pheochromocytomas. This relationship is hypothesized to be based on altered Ca 2+ homeostasis due to increased intestinal Ca 2+ absorption. Other agents associated with pheochromocytomas in rats in long-term toxicity studies have been shown to increase chromaffin cell proliferation, leading to the suggestion that the tumors occur secondarily to increased chromaffin cell turnover. We have demonstrated marked stimulation of chromaffin cell proliferation by vitamin D 3 , a potent stimulus to Ca 2+ absorption not previously associated with adrenal medullary toxicity. This effect is detectable during the first week of dietary supplementation and persists throughout a 4-week time course. Lactose and xylitol, representative of sugars and sugar alcohols associated with pheochromocytomas, are also mitogenic but to a lesser extent, with their effects first detectable during Week 4 of dietary supplementation. Vitamin D 3 , its active metabolite calcitriol, lactose, and xylitol all fail to stimulate proliferation of rat chromaffin cells in vitro. The mitogenic effects of these agents may be mediated presynaptically in vivo. The data suggest that altered Ca 2+ homeostasis may increase chromaffin cell proliferation and support the hypothesis that diets containing high concentrations of sugars and sugar alcohols cause pheochromocytomas in rats secondarily by this mechanism. |
| Databáze: | OpenAIRE |
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