A case-control study of sporadic Creutzfeldt-Jakob disease in Switzerland: analysis of potential risk factors with regard to an increased CJD incidence in the years 2001–2004
| Autor: | Klaus Hess, Lorenz Amsler, Thomas Blaettler, Tobias Eckert, Markus Glatzel, Adriano Aguzzi, Jessica Ruegger, Katharina Stoeck, Marcel Zwahlen |
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| Přispěvatelé: | University of Zurich, Eckert, T |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Pathology 10208 Institute of Neuropathology Prevalence 610 Medicine & health Severity of Illness Index Creutzfeldt-Jakob Syndrome Age Distribution Risk Factors Recall bias Epidemiology Confidence Intervals Odds Ratio Humans Medicine Medical history Sex Distribution Family history Aged Probability Retrospective Studies business.industry Incidence Incidence (epidemiology) lcsh:Public aspects of medicine Public Health Environmental and Occupational Health Retrospective cohort study lcsh:RA1-1270 2739 Public Health Environmental and Occupational Health Odds ratio Middle Aged Survival Analysis 10040 Clinic for Neurology Logistic Models Case-Control Studies 570 Life sciences biology Female business Switzerland Research Article Demography |
| Zdroj: | BMC Public Health, Vol 9, Iss 1, p 18 (2009) Ruegger, Jessica; Stoeck, Katharina; Amsler, Lorenz; Blaettler, Thomas; Zwahlen, Marcel; Aguzzi, Adriano; Glatzel, Markus; Hess, Klaus; Eckert, Tobias (2009). A case-control study of sporadic Creutzfeldt-Jakob disease in Switzerland: analysis of potential risk factors with regard to an increased CJD incidence in the years 2001-2004. BMC public health, 9(1), p. 18. London: BioMed Central 10.1186/1471-2458-9-18 BMC Public Health |
| ISSN: | 1471-2458 |
| DOI: | 10.1186/1471-2458-9-18 |
| Popis: | Background In 2001, the observed annual mortality from Creutzfeldt-Jakob disease (CJD) in Switzerland increased from less than 1.5 to 2.6 per million inhabitants. An underlying cause could not be identified. Methods To analyse potential risk factors for sCJD in Switzerland, close relatives of 69 sCJD-patients and 224 frequency age-matched controls were interviewed in a case-control study using a standardised questionnaire. 135 potential risk factors including socio-demographics, medical history, occupation and diet were analysed by logistic regression adjusting for age, sex and education. Results sCJD patients were more likely to have travelled abroad, worked at an animal laboratory, undergone invasive dental treatment, orthopaedic surgery, ophthalmologic surgery after 1980, regular GP visits, taken medication regularly, and consumed kidney. No differences between patients and controls were found for residency, family history, and exposure to environmental and other dietary factors. Conclusion Although some factors were significantly more frequent among sCJD-cases, this study did not reveal specific explanations for the increased incidence of deaths due to sporadic CJD observed in Switzerland since 2001. Results have to be interpreted with caution due to multiple testing and possible recall bias in association with a long incubation period. The most plausible reason for the increase in Swiss sCJD cases after 2000 is an improved case ascertainment. Therefore, underreporting of cases might well have occurred before the year 2001, and the "real" yearly incidence of sCJD might not be lower than, but rather above 2 per million inhabitants. |
| Databáze: | OpenAIRE |
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