Cardiac assessment in Wilson’s disease patients based on electrocardiography and echocardiography examination
| Autor: | Tomasz Litwin, Małgorzata Buksińska-Lisik, Anna Członkowska, Tomasz Pasierski |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
hepatolenticular degeneration
medicine.medical_specialty left ventricular diastolic dysfunction Diastole lcsh:Medicine 030204 cardiovascular system & hematology Left ventricular hypertrophy 03 medical and health sciences 0302 clinical medicine Tissue Doppler echocardiography Clinical Research Internal medicine medicine Sinus rhythm Ejection fraction medicine.diagnostic_test business.industry lcsh:R General Medicine medicine.disease left ventricular hypertrophy Wilson's disease medicine.anatomical_structure Ventricle Cardiology business Electrocardiography 030217 neurology & neurosurgery |
| Zdroj: | Archives of Medical Science, Vol 15, Iss 4, Pp 857-864 (2017) Archives of Medical Science : AMS |
| ISSN: | 1734-1922 |
| Popis: | Introduction Wilson’s disease (WD) is a rare genetic disorder that leads to impairments in copper metabolism. Patients principally exhibit liver and neuropsychiatric symptoms, but because copper also accumulates in all body organs, other (typically milder) clinical symptoms can occur. To date, cardiac involvement has not been thoroughly investigated in patients with WD. This study aimed to evaluate heart structure and function in patients with WD with commonly available diagnostic methods. Material and methods We compared 125 WD patients with an age- and sex-matched control group. Patients with WD were grouped according to their dominant symptoms – neurologic or hepatic. All subjects underwent clinical, electrocardiographic (ECG), and echocardiographic examinations. Results All subjects had sinus rhythm on electrocardiography. The only ECG parameter that differed between patients with WD and the control group was the QRS prolongation (92.0 vs. 86.4 ms; p < 0.05). On echocardiography patients with WD exhibited more hypertrophy in the left ventricle than controls (posterior wall in diastole: 1.0 vs. 0.93; p < 0.01) and the left ventricle hypertrophy was more pronounced in the neurologic than in the hepatic subgroup (1.05 vs. 0.96 cm; p < 0.01). Left ventricular systolic function was similar in the WD and the control group (ejection fraction: 67.5% vs. 67.7%). On tissue Doppler echocardiography patients with WD demonstrated slowing of myocardial relaxation, which was more evident in the neurologic group. Conclusions Heart involvement in WD was manifested mainly by mild left ventricular hypertrophy and subclinical changes in diastolic function, particularly in the patients with the neurologic form of disease. |
| Databáze: | OpenAIRE |
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