Serum insulin-like growth factor-I and pro-collagen type III N-terminal peptide in adolescent elite athletes: implications for the detection of growth hormone abuse in sport
| Autor: | Joanna Brigg, E. Eryl Bassett, Tamsin Drake, Nishan Guha, David A. Cowan, Christiaan Bartlett, Peter H. Sönksen, Caroline Burford, Richard I. G. Holt, Gail Strobridge, Ioulietta Erotokritou-Mulligan |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Aging Adolescent Cross-sectional study Endocrinology Diabetes and Metabolism Clinical Biochemistry Population Context (language use) Biochemistry Body Mass Index Epitopes Young Adult Endocrinology Internal medicine medicine Humans False Positive Reactions Young adult Insulin-Like Growth Factor I education Child Doping in Sports education.field_of_study Sex Characteristics biology Athletes business.industry Human Growth Hormone Biochemistry (medical) Body Weight Reproducibility of Results biology.organism_classification medicine.disease Obesity Body Height Substance Abuse Detection Collagen Type III Cross-Sectional Studies Female business Body mass index Procollagen Sex characteristics Sports |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 95(6) |
| ISSN: | 1945-7197 |
| Popis: | Context: A method based on two GH-dependent markers, IGF-I and pro-collagen type III N-terminal peptide (P-III-P), has been devised to detect exogenously administered GH. Because previous studies on the detection of GH abuse involved predominantly adult athletes, the method must be validated in adolescent athletes. Objective: The aim of the study was to examine serum IGF-I and P-III-P concentrations in elite adolescent athletes and to determine whether the method developed in adults is appropriate to detect GH abuse in this population. Design and Setting: We conducted a cross-sectional observational study at national sporting organization training events. Subjects: A total of 157 (85 males, 72 females) elite athletes between 12 and 20 yr of age participated in the study. Intervention: Serum IGF-I and P-III-P were each measured by two commercially available immunoassays. GH-2000 discriminant function scores were calculated. Results: Both IGF-I and P-III-P rose to a peak during adolescence, which was earlier in girls than in boys. All GH-2000 scores lay below the proposed cutoff limit of 3.7 (although some scores were close to this value), indicating that none of these athletes would be accused of GH doping if the GH-2000 discriminant formulae were used. The results between the two immunoassays for IGF-I and P-III-P were closely aligned. Conclusions: The GH-2000 score rises in early adolescence, reaches a peak in athletes aged 13–16 yr, and then falls. We have found no evidence that the proposed GH-2000 score developed in adults would lead to an unacceptable rate of false-positive results in adolescent athletes, but caution may be required around the time of peak growth velocity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|