CD73; a key ectonucleotidase in the development of breast cancer: Recent advances and perspectives
| Autor: | Hatam Rashidpour, Arash Jafari, Shirin Shahsavari, Eskandar Taghizadeh, Anvar Soleimani, Mahmoud Reza Jaafari, Mohammad Soukhtanloo, Kazem Mashayekhi, Esmaeel Azadian, Yousef Amini, Mohammad Reza Parizadeh |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Tumor microenvironment Cell signaling Physiology business.industry Clinical Biochemistry Tumor Cell Invasion Cell Biology Hypoxia (medical) medicine.disease Metastasis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Breast cancer Downregulation and upregulation 030220 oncology & carcinogenesis Cancer research Medicine Ectonucleotidase medicine.symptom business |
| Zdroj: | Journal of cellular physiology. |
| ISSN: | 1097-4652 |
| Popis: | Tumor cell invasion and metastasis are the definitive cause of mortality in breast cancer (BC). Hypoxia and pro-inflammatory cytokines upregulate the CD73 gene in the tumor microenvironment. Subsequently, CD73 triggers molecular and cellular signaling pathways by both enzymatic and nonenzymatic pathways, which finally leads to breast tumor progression and development. In this paper, we summarize current advances in the understanding of CD73-driven mechanisms that promote BC development and mortality. Furthermore, we evaluate the therapeutic potential of CD73 targeting in BC. |
| Databáze: | OpenAIRE |
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