The effect of centrally administered erythropoietin on cardiovascular and respiratory system of anaesthetized rats

Autor: Murat Yalcin, Melih Erturk, Fusun Ak, I. Taci Cangul
Přispěvatelé: Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı., Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı., Yalçın, Murat, Ak, Füsun, Cangül, İ. Taci, Ertürk, Melih, AAB-4360-2021, AAG-6956-2021
Rok vydání: 2006
Předmět:
Central Nervous System
Expression
Pressor response
Blood Pressure
Pharmacology
Rats
Sprague-Dawley
Lung minute volume
Heart Rate
hemic and lymphatic diseases
Tachycardia
Hippocampal
Anesthesia
Respiratory system
Tidal volume
Inhibition
Priority journal
Neurons
Neurotransmitter Agents
Neuroprotection
Cardiovascular system
Intracerebroventricular
Injections
Intravenous
Female
Drug mechanism
Recombinant-human-erythropoietin
Receptor
medicine.drug
Respiratory rate
Minute ventilation
Breathing rate
Neurosciences & neurology
Article
Xylazine
Cellular and Molecular Neuroscience
Cerebral-ischemia
medicine
Tidal Volume
Animals
Respiratory frequency
Ketamine
Animal experiment
Erythropoietin
Injections
Intraventricular
Cibinetide
Darbepoetin Alfa
Endocrine and Autonomic Systems
business.industry
Nonhuman
Ventilation
Rats
Drug effect
Blood pressure
Localization
Respiratory Mechanics
Rat
Neurology (clinical)
business
Controlled study
Respiratory minute volume
Zdroj: Autonomic neuroscience : basicclinical. 134(1-2)
ISSN: 1566-0702
Popis: Erythropoietin (EPO) is a hematopoietic factor, which is produced primarily by the adult kidney in response to tissue hypoxia. There is strong evidence that EPO may also be synthesized in the brain and act as a neuroprotector or neuromodulator in the central nervous system. The present study investigated the effect of centrally administered EPO on cardiovascular and respiratory parameters in anaesthetized rats. The animals were anaesthetized with ketamine (70 mg/kg) and xylazine (10 mg/kg) mixture. EPO at doses of 0.06, 0.12, 0.25 and 0.50 IU/5 μl or 0.9% saline as a control were injected intracerebroventricularly and blood pressure, heart rate, respiratory rate, tidal volume and minute ventilation were recorded. Following the administration of EPO, there was a significant increase in blood pressure, heart and respiratory rates, tidal volume and minute ventilation which were time and dose dependant. In order to investigate whether these effects of centrally injected EPO was caused by the diffusion of the drug to the periphery, the highest dose EPO (0.5 IU) in the present study, was injected intravenously but intravenously injected EPO showed no significant effect in these parameters. In conclusion, our findings showed that centrally injected erythropoietin caused pressor and tachycardic response, an increase in respiratory frequency and volume in anaesthetized rats. Moreover intravenous injection of the highest dose of EPO used in the study caused no effect suggesting a central mechanism of action for the agent. Hence, one can hypothesize that erythropoietin may play a role in the central regulation of cardiovascular and respiratory system as a neuromodulator or neuromediator.
Databáze: OpenAIRE
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