Biochemical and biomechanical properties of avian callus after local administration of dihydroxylated vitamin D metabolites
| Autor: | Cobi Lidor, Hallel T, Blaugrund E, M S Meyer, Samuel Edelstein, Dekel Samuel |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Vitamin medicine.medical_specialty 24 25-Dihydroxyvitamin D 3 chemistry.chemical_compound Vitamin D+Metabolites Calcitriol Internal medicine Animals Medicine Orthopedics and Sports Medicine Tibia Bony Callus Drug Implants business.industry Alkaline Phosphatase Biomechanical Phenomena Endochondral bone formation Tibial Fractures Endocrinology chemistry Callus Alkaline phosphatase Calcium Surgery Stress Mechanical business Cholecalciferol Chickens |
| Zdroj: | The Journal of Bone and Joint Surgery. British volume. :137-140 |
| ISSN: | 2044-5377 0301-620X |
| DOI: | 10.1302/0301-620x.72b1.2298772 |
| Popis: | In vitamin D-fed chicks 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 were implanted into experimentally-produced fractures of the mid-tibia. The mechanical and biochemical properties of the tibia were evaluated for two weeks, including torsion tests, measurement of alkaline phosphatase activity, 45Ca incorporation, and Ca2+ content. Both dihydroxylated metabolites of vitamin D3 had a direct effect on endochondral bone formation. 24,25(OH)2D3 strengthened the callus, and raised alkaline phosphate activity in the first seven days after fracture. 1,25(OH)2D3 decreased the strength of the callus concomitant with a reduction in 45Ca incorporation. It is suggested that local application of 24,25(OH)2D3 into fractures may accelerate healing and prevent non-union. |
| Databáze: | OpenAIRE |
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