Real-Time in situ Raman Analysis of Microwave-Assisted Organic Reactions
| Autor: | Don E. Pivonka, James Empfield |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Chemical process
Reaction mechanism Reactive intermediate Nanotechnology Spectrum Analysis Raman Online Systems symbols.namesake chemistry.chemical_compound Electromagnetic Fields Fiber Optic Technology Organic Chemicals Microwaves Instrumentation Spectroscopy Chemistry Microchemistry Temperature Equipment Design Equipment Failure Analysis Organic reaction symbols Feasibility Studies Knoevenagel condensation Organic synthesis Raman spectroscopy Microwave |
| Zdroj: | Applied Spectroscopy. 58:41-46 |
| ISSN: | 1943-3530 0003-7028 |
| DOI: | 10.1366/000370204322729450 |
| Popis: | Integration of a Raman probe into a commercially available microwave synthesizer has demonstrated unprecedented utility in understanding chemical processes within the rapidly emerging field of microwave-assisted organic synthesis. The real-time spectral feedback afforded by this system has facilitated analysis of reaction mechanisms, reactive intermediates, and reaction kinetics via optical sampling through the sidewall of the sealed reaction vial within the microwave chamber. The feasibility, attributes, and limitations of the system are illustrated using amine coupling and Knoevenagel coupling example reactions. In addition to the reported analyses, this system provided the safety of remote sensing, adequate sensitivity, ease of alignment, and optimized “depth of field” for analysis of solutions with solids content. |
| Databáze: | OpenAIRE |
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