Effect of guided bone regeneration on bone quality surrounding dental implants
| Autor: | In-Chul Rhyu, Ben Siderits, Trenton B. Johnson, F. Michael Beck, Seung-Hee Han, Do-Gyoon Kim, Yong-Hoon Jeong, Jung-Suk Han, Seth Nye, Toru Deguchi |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Bone Regeneration medicine.medical_treatment 0206 medical engineering Biomedical Engineering Biophysics Implantation Site Bone Matrix Bone Morphogenetic Protein 2 Dentistry Mandible 02 engineering and technology Bone tissue Article 03 medical and health sciences Dogs 0302 clinical medicine Transforming Growth Factor beta Elastic Modulus Bone quality medicine Animals Orthopedics and Sports Medicine Dental implant Bone regeneration Dental Implants Titanium Wound Healing business.industry Demineralized bone matrix Dental Implantation Endosseous Rehabilitation dBm 030206 dentistry 020601 biomedical engineering Recombinant Proteins medicine.anatomical_structure Guided Tissue Regeneration Periodontal Implant business |
| Zdroj: | Journal of Biomechanics. 80:166-170 |
| ISSN: | 0021-9290 |
| DOI: | 10.1016/j.jbiomech.2018.08.011 |
| Popis: | Bone quality as well as its quantity at the implant interface is responsible for determining stability of the implant system. The objective of this study is to examine the nanoindentation based elastic modulus (E) at different bone regions adjacent to titanium dental implants with guided bone regeneration (GBR) treated with DBM and BMP-2 during different post-implantation periods. Six adult male beagle dogs were used to create circumferential defects with buccal bone removal at each implantation site of mandibles. The implant systems were randomly assigned to only GBR (control), GBR with demineralized bone matrix (DBM), and GBR with DBM + recombinant human bone morphogenetic protein-2 (rhBMP-2) (BMP) groups. Three animals were sacrificed at each 4 and 8 weeks of post-implantation healing periods. Following buccolingual dissection, the E values were assessed at the defects (Defect), interfacial bone tissue adjacent to the implant (Interface), and pre-existing bone tissue away from the implant (Pre-existing). The E values of BMP group had significantly higher than control and DBM groups for interface and defect regions at 4 weeks of post-implantation period and for the defect region at 8 weeks (p 0.043). DBM group had higher E values than control group only for the defect region at 4 weeks (p 0.001). The current results indicate that treatment of rhBMP-2 with GBR accelerates bone tissue mineralization for longer healing period because the GBR likely facilitates a microenvironment to provide more metabolites with open space of the defect region surrounding the implant. |
| Databáze: | OpenAIRE |
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