Geranisetron versus gabapentin in preventing postoperative nausea and vomiting after middle ear surgery in adults: A double-blinded randomized clinical trial study
| Autor: | Farnaz Khalighinejad, Mohammadreza Safavi, Morteza Heidari, Azim Honarmand, Mohsen Chitsazi |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
5HT3 receptors Gabapentin Double blinded gabapentin lcsh:Medicine Granisetron law.invention Randomized controlled trial law otorhinolaryngologic diseases medicine lcsh:QH301-705.5 visual analogues scale business.industry Incidence (epidemiology) lcsh:R General Medicine Surgery American social anesthesia lcsh:Biology (General) Middle ear surgery Anesthesia Original Article Premedication sense organs medicine.symptom geranisetrone business post operating nausea and vomiting (PONV) Postoperative nausea and vomiting medicine.drug |
| Zdroj: | Advanced Biomedical Research, Vol 4, Iss 1, Pp 22-22 (2015) Advanced Biomedical Research |
| ISSN: | 2277-9175 |
| DOI: | 10.4103/2277-9175.150388 |
| Popis: | Background: The incidence of postoperative nausea and vomiting (PONV) after middle ear surgery is high. In this study we want to compare the effects of intravenous granisetron and oral gabapentin as a premedication before surgery on the incidence and severity of PONV after middle ear surgery in adult patents. Materials and Methods: We enrolled 90 patients that were randomly divided into the three groups of 30 in each. Group I received granisetron 3 mg iv 2 minutes before induction of anesthesia; Group II received oral gabapentin 300 mg 1 hour before anesthesia and Group III received placebo. The incidence and severity of PONV were recorded each 15 minutes in the post-anesthesia care unit (PACU) and each 8 hours until 24 hours after discharge from the PACU. Result: The incidence and severity of nausea and vomiting at different time intervals in Groups I and Group II was significantly lower compared with Group III (P < 0.05). There was no significant difference in the incidence of side effects of study drug administration including respiratory depression, apnea, extra pyramidal disorders, drowsiness, dizziness, vertigo and headache in three groups. Conclusion: The study was shown that using gabapentin and granisetron have equal anti-emetic effects, but significant differences were seen between these two groups compared to the control group. These submit the efficiency of these drugs in preventing PONV. |
| Databáze: | OpenAIRE |
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